Ligand guanidine

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Basic Ligand Information

Molecular Structure
Picture of guanidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH5N3
guanidine
ZRALSGWEFCBTJO-UHFFFAOYSA-N
Synonyms:
guanidinium, guanidinium ion, guanidinium ions, iminourea

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
guanidine + NAD+ = nicotinamide + ?
show the reaction diagram
-
ATP + guanidine = ADP + phosphoguanidine
show the reaction diagram
-
guanidine + H2O = ? + NH3
show the reaction diagram
-
guanidine + H2O = NH3 + urea
show the reaction diagram
-
guanidine + H2O = urea + NH3
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
-
-
2'-O-methylguanosine + H2O = 2-O-methylribose + guanidine
show the reaction diagram
-
-
ADP-ribosylguanidine + H2O = ADP-ribose + guanidine
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
can activate oxidized enzyme
-
no effect on wild-type but guanidine causes a 45fold enhancement of mutant R507A activity
-
i.e. GuH+, involved in the thermal stability and activity equilibrium of the enzyme complex, overview
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Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inactivation, unfolding
-
slight
-
blocks the initiation step of RNA synthesis in vitro
-
the enzyme maintains approximately 70 and 60% of proteolytic activity at 100 and 150 mM guanidine, respectively
-
competitive
brain enzyme, 5 M: 100% reversible inhibition, 95% of original activity is recovered upon lowering the guanidine concentration by dilution
-

Metals and Ions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-

3D Structure of Enzyme-Ligand-Complex (PDB) (168 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0015
-
-
3.39
-
pH 7.5, 37°C

References & Links

Links to other databases for guanidine

ChEBI
PubChem
ChEBI
PubChem