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Ligand cis-vaccenic acid Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 8 H3 4 O2
cis-vaccenic acid
UWHZIFQPPBDJPM-FPLPWBNLSA-N
asclepic acid, cis-vaccenate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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ATP + cis-vaccenic acid + [acyl-carrier protein] = AMP + diphosphate + cis-vaccenoyl-[acyl-carrier protein]
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Product in Enzyme-catalyzed Reactions (2 results)
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cis-vaccenoyl-CoA + H2O = CoA + cis-vaccenate
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cis-vaccenoyl-CoA + H2O = CoA + cis-vaccenic acid
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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50% inhibition at 0.50 mM
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0.45 mM, 50% inhibition, synergism with cis-9,10-methylenehexadecanoic acid
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synonym: cis-11-octadecenoic acid
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Enzyme Kinetic Parameters
References & Links Literature References (4)
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Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli
1976
Ray, T.K.; Cronan, J.E.
Proc. Natl. Acad. Sci. USA
73
4374-4378
Inhibition of L-glycerol 3-phosphate acyltransferase from Escherichia coli by cis-9,10-methylenehexadecanoic acid
1972
Kito, M.; Aibara, S.; Hasegawa, K.; Hata, T.
J. Biochem.
71
99-105
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Partial purification and characterization of 4-hydroxybenzoate-polyprenyltransferase in ubiquinone biosynthesis of Pseudomonas putida
1991
Kawahara, K.; Koizumi, N.; Kawaji, H.; Oishi, K.; Aida, K.; Uchida, K.
Agric. Biol. Chem.
55
2307-2311
Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5alpha-reductase
2002
Matsuda, H.; Yamazaki, M.; Naruo, S.; Asanuma, Y.; Kubo, M.
Biol. Pharm. Bull.
25
622-626
Links to other databases for cis-vaccenic acid
Show all BRENDA pathways known for cis-vaccenic acid
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