Ligand cytosine arabinoside

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Basic Ligand Information

Molecular Structure
Picture of cytosine arabinoside (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H13N3O5
cytosine arabinoside
UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Synonyms:
1-(beta-D-arabinofuranosyl)-cytosine, 1-beta-D-arabinofuranosylcytosine, 1-beta-D-arabinofuranosyl cytosine, arabinocytidine, arabinofuranosylcytosine, arabinosylcytosine, arabinosyl cytosine, ara C, beta-D-arabinofuranosylcytosine, cytarabine, cytarabine[side 1], cytarabine[side 2], cytosine beta-D-arabinofuranoside

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + cytarabine = ADP + phospho-cytarabine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + cytarabine = ADP + cytarabine 5'-monophosphate
show the reaction diagram
-
ATP + arabinosyl cytosine = ?
show the reaction diagram
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ATP + 1-beta-D-arabinofuranosyl cytosine = ADP + 1-beta-D-arabinofuranosyl cytosine 5'-phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O = L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.0534 mM for reaction with thymidine and 0.089 mM for reaction with 2'-deoxycytidine
-
ara-C, deactivating dCMP deaminase
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (36 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.109
-
pH 7.5

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0534
-
IC50: 0.0534 mM for reaction with thymidine and 0.089 mM for reaction with 2'-deoxycytidine
0.0000055
-
IC50 0.0000055 mM

References & Links

Links to other databases for cytosine arabinoside

ChEBI
PubChem
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PubChem