Ligand baclofen

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of baclofen (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12ClNO2
baclofen
KPYSYYIEGFHWSV-UHFFFAOYSA-N

Show all pahtways known for Show all pathways known for baclofen

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
hypothesis: stimulate Na+/K+ transport via specific receptor inputs
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
injection of 0.01 mg/g body weight reduces GABA-T mRNA level 2fold; i.p. injection of sexually regressed female goldfish results in significant increase in serum luteinising hormone after 6 h. About 2fold decrease both in glutamic acid decarboxylase 67 and gamma-aminobutanoate transaminase mRNa in the hypothalamus
-
98% residual activity at 0.5 mM
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for baclofen

ChEBI
PubChem
ChEBI
PubChem