Ligand 8-azido-GTP

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Basic Ligand Information

Molecular Structure
Picture of 8-azido-GTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15N8O14P3
8-azido-GTP
JOEORHHXHRXYIW-UMMCILCDSA-N
Synonyms:
8-azidoguanosine 5'-triphosphate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-azido-GTP + H2O = 8-azido-GDP + phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
used for affinity photolabeling, 0.1 mM, 95% inhibition
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0.6 mM, 91% inhibition of GTP cyclohydrolase activity, 0.3 mM, 53% inhibition of diphosphate phosphohydrolase activity
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photoinactivation is caused by formation of an intramolecular cystine disulfide bridge
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Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.005
-
-

References & Links

Links to other databases for 8-azido-GTP

ChEBI
PubChem
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PubChem