Ligand TNF-alpha

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Basic Ligand Information

Molecular Formula
BRENDA Name
InChIKey
TNF-alpha

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TNF-alpha + H2O = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
TNF-alpha + H2O = ?
show the reaction diagram
-
TNF-alpha + H2O = ?
show the reaction diagram
-
TNF-alpha + H2O = ?
show the reaction diagram
-
TNF-alpha + H2O = ?
show the reaction diagram
-
TNF-alpha + H2O = ?
show the reaction diagram
-
TNF-alpha + H2O = ?
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
up-regulating of ACAT1 expression
-
activates PI3K
-
2.8fold activation of class II isoform PI3K-C2beta by activation of the ERK pathway, blockade of activation by MEK-inhibitor PD98059
-
treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus
-
stimulates the autophosphorylation of Goodpasture antigen-binding protein
-
increases N-SMase activity rapidly and transiently both endogenously and in cells overexpressing nSMase2, and induces membrane translocation of nSMase2, regulated by p38-alpha MAPK, the increase in endogenous N-SMase activity is abrogated by p38 MAPK inhibition
-
stimulation in a dose-dependent manner
-
acts synergistically with interleukin 1-beta to increase gene expression and activity
-
cathepsin S can be upregulated by TNF-alpha in endothelial cells and cathepsin S induces endothelial cell motility, invasion and migration
-
activates cytosolic enzyme
-
induces caspase-3 activation
-
10 ng/ml
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
250 U/ml, 63% relative activity
-
suppresses the expression of histidase
-

Enzyme Kinetic Parameters

References & Links

Links to other databases for TNF-alpha