Ligand Beta-cyanoalanine

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Basic Ligand Information

Molecular Structure
Picture of Beta-cyanoalanine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6N2O2
Beta-cyanoalanine
BXRLWGXPSRYJDZ-VKHMYHEASA-N
Synonyms:
3-Cyano-L-Ala, 3-Cyano-L-alanine, 3-cyanoalanine, beta-cyano-L-Ala, Beta-cyano-L-alanine, cyanoalanine, L-3-cyanoalanin, L-3-cyanoalanine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-cyano-L-alanine + H2O = L-aspartate + NH3
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cysteine + CN- = cyanoalanine + H2S
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-cyano-L-Ala + H2O = ?
show the reaction diagram
-
beta-cyanoalanine + H2O = ?
show the reaction diagram
-
beta-cyanoalanine + H2O = alanine + NH3
show the reaction diagram
-
beta-cyano-L-alanine + H2O = asparagine + aspartic acid
show the reaction diagram
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3-cyano-L-alanine = ?
show the reaction diagram
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ATP + L-Glu + beta-cyano-L-alanine = ADP + phosphate + gamma-L-Glu-beta-cyano-L-alanine
show the reaction diagram
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ATP + UDP-N-acetylmuramate + beta-cyano-L-Ala = ADP + phosphate + UDP-N-acetylmuramoyl-beta-cyano-L-Ala
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cysteine + cyanide = cyanoalanine + H2S
show the reaction diagram
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-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive towards L-Asp
-

Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
42% inhibition of the O-acetyl-L-serine sulfhydrylation reaction
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10 mM, 36% inhibition and 20 mM, 50% inhibition
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aminoacylation of Asn, competitive
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poor
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
26.7
-
-

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.8
-
ATP-diphosphate exchange
0.19
-
-

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.014
-
pH 8.2, 37°C

References & Links

Links to other databases for Beta-cyanoalanine

ChEBI
PubChem
ChEBI
PubChem