Ligand tacrine

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C13H14N2
tacrine
YLJREFDVOIBQDA-UHFFFAOYSA-N
Synonyms:
1,2,3,4-tetrahydroacridin-9-amine, 9-Amino-1,2,3,4-tetrahydroacridine

Show all pahtways known for Show all pathways known for tacrine

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
-

Inhibitor in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.0050 mM, 50% inhibition
-
i.e. tacrine, competitive inhibition
-
i.e. 1,2,3,4-tetrahydroacridin-9-amine
-
inhibitor binding to Zn2+-free enzyme, dissociation constant 0.0017 mM, EC50 value 0.060 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (5 results)

Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.14
-
-
0.0000382
-
-

IC50 Value (19 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for tacrine

ChEBI
PubChem
ChEBI
PubChem