Ligand [p53 protein]-N6-acetyl-L-lysine
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Basic Ligand Information
[p53 protein]-N6-acetyl-L-lysine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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NAD+ + [p53 protein]-N6-acetyl-L-lysine = nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
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Substrate in Enzyme-catalyzed Reactions (1 result)
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NAD+ + [p53 protein]-N6-acetyl-L-lysine = nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
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Enzyme Kinetic Parameters
References & Links
Literature References (1)
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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
2002
Langley, E.; Pearson, M.; Faretta, M.; Bauer, U.M.; Frye, R.A.; Minucci, S.; Pelicci, P.G.; Kouzarides, T.
EMBO J.
21
2383-2396
Links to other databases for [p53 protein]-N6-acetyl-L-lysine