Ligand Prostaglandin D2

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Basic Ligand Information

Molecular Structure
Picture of Prostaglandin D2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H32O5
Prostaglandin D2
BHMBVRSPMRCCGG-OUTUXVNYSA-N
Synonyms:
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate, (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate, 13(S)-prostaglandin H2, prostaglandin PGD2


Show all pahtways known for Show all BRENDA pathways known for Prostaglandin D2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prostaglandin D2 + NADP+ = 15-ketoprostaglandin D2 + NADPH + H+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prostaglandin D2 + NADPH = ?
show the reaction diagram
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(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
show the reaction diagram
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prostaglandin D2 + NADP+ = 15-ketoprostaglandin D2 + NADPH + H+
show the reaction diagram
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prostaglandin D2 + NADPH + H+ = 9alpha,11beta-prostaglandin F2 + NADP+
show the reaction diagram
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prostaglandin D2 + [reduced NADPH-hemoprotein reductase] + O2 = 20-hydroxy-prostaglandin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
up to 100% increase in activity
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (25 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.741
-
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IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for Prostaglandin D2

ChEBI
PubChem
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PubChem