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Ligand (E)-4-(trimethylammonio)but-2-enoyl-CoA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 8 H4 7 N8 O1 7 P3 S
(E)-4-(trimethylammonio)but-2-enoyl-CoA
WAUPBDVHJXXZGW-HXPULJKESA-O
Show all BRENDA pathways known for (E)-4-(trimethylammonio)but-2-enoyl-CoA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)
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crotonobetainyl-CoA + reduced electron-transfer flavoprotein = gamma-butyrobetainyl-CoA + electron-transfer flavoprotein
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(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O = L-carnitinyl-CoA
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crotonobetainyl-CoA + H2O = L-carnitinyl-CoA
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O
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L-carnitinyl-CoA = crotonobetainyl-CoA + H2O
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Substrate in Enzyme-catalyzed Reactions (6 results)
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crotonobetainyl-CoA + reduced benzylviologen = gamma-butyrobetainyl-CoA + oxidized benzylviologen
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crotonobetainyl-CoA + reduced electron-transfer flavoprotein = gamma-butyrobetainyl-CoA + electron-transfer flavoprotein
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(E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA
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crotonobetainyl-CoA + L-carnitine = crotonobetaine + L-carnitinyl-CoA
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(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O = L-carnitinyl-CoA
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crotonobetainyl-CoA + H2O = L-carnitinyl-CoA
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Product in Enzyme-catalyzed Reactions (4 results)
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gamma-butyrobetainyl-CoA + electron-transfer flavoprotein = crotonobetainyl-CoA + reduced electron-transfer flavoprotein
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L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O
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L-carnitinyl-CoA = crotonobetainyl-CoA + H2O
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ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA
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Enzyme Kinetic Parameters
KM Value (2 results)
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at pH 7.5 and 37°C
0.012
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References & Links Literature References (5)
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Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
2005
Engemann, C.; Elssner, T.; Pfeifer, S.; Krumbholz, C.; Maier, T.; Kleber, H.P.
Arch. Microbiol.
183
176-189
Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism
2004
Stenmark, P.; Gurmu, D.; Nordlund, P.
Biochemistry
43
13996-14003
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
2001
Engemann, C.; Elssner, T.; Kleber, H.P.
Arch. Microbiol.
175
353-359
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli
2001
Elssner, T.; Engemann, C.; Baumgart, K.; Kleber, H.P.
Biochemistry
40
11140-11148
Isolation, identification, and synthesis of gamma-butyrobetainyl-CoA and crotonobetainyl-CoA, compounds involved in carnitine metabolism of E. coli
2000
Elssner, T.; Hennig, L.; Frauendorf, H.; Haferburg, D.; Kleber, H.P.
Biochemistry
39
10761-10769
Links to other databases for (E)-4-(trimethylammonio)but-2-enoyl-CoA