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Ligand benzoyl-GVL(N6-malonyl)KEYGV-amide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.B43

NAD+ + benzoyl-GVL(N6-malonyl)KEYGV-amide = nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-malonyl-ADP-ribose

728962

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.1.B43

0.019

-

pH 7.8, 37°C

728962

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.B43

0.0051

-

pH 7.8, 37°C

728962

References & Links

Literature References (1)

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BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

728962

25111069

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors

2014

Roessler, C.; Nowak, T.; Pannek, M.; Gertz, M.; Nguyen, G.T.; Scharfe, M.; Born, I.; Sippl, W.; Steegborn, C.; Schutkowski, M.

Angew. Chem. Int. Ed. Engl.

53

10728-10732

Links to other databases for benzoyl-GVL(N6-malonyl)KEYGV-amide

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ChEBI

PubChem

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