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Ligand N6-dimethylallyladenine37 in tRNA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
N6-dimethylallyladenine37 in tRNA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
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Substrate in Enzyme-catalyzed Reactions (3 results)
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N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine
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N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine = 2-thio-N6-dimethylallyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenosine
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N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine
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Product in Enzyme-catalyzed Reactions (1 result)
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dimethylallyl diphosphate + adenine37 in tRNA = diphosphate + N6-dimethylallyladenine37 in tRNA
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Enzyme Kinetic Parameters
References & Links Literature References (8)
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N6-(delta-2-isopentenyl) adenosine. Biosynthesis in transfer ribonucleic acid in vitro
1969
Kline, L.K.; Fittler, F.; Hall, R.H.
Biochemistry
8
4361-4371
DELTA 2 -isopentenylpyrophosphate: transfer ribonucleic acid 2 -isopentenyltransferase from Escherichia coli. Purification and properties of the enzyme
1972
Rosenbaum, N.; Gefter, M.L.
J. Biol. Chem.
247
5675-5680
N6-(2-isopentenyl) adenosine: biosynthesis in vitro in transfer RNA by an enzyme purified from Escherichia coli
1972
Bartz, J.K.; Soell, D.
Biochimie
54
31-39
tRNA isopentenyltransferase from Lactobacillus acidophilus ATCC 4963
1975
Holtz, J.; Klämbt, D.
Hoppe-Seyler's Z. Physiol. Chem.
356
1459-1464
MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase
2003
Pierrel, F.; Hernandez, H.L.; Johnson, M.K.; Fontecave, M.; Atta, M.
J. Biol. Chem.
278
29515-29524
Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB
2013
Landgraf, B.J.; Arcinas, A.J.; Lee, K.H.; Booker, S.J.
J. Am. Chem. Soc.
135
15404-15416
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA
2004
Pierrel, F.; Douki, T.; Fontecave, M.; Atta, M.
J. Biol. Chem.
279
47555-47563
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases
2013
Forouhar, F.; Arragain, S.; Atta, M.; Gambarelli, S.; Mouesca, J.M.; Hussain, M.; Xiao, R.; Kieffer-Jaquinod, S.; Seetharaman, J.; Acton, T.B.; Montelione, G.T.; Mulliez, E.; Hunt, J.F.; Fontecave, M.
Nat. Chem. Biol.
9
333-338
Links to other databases for N6-dimethylallyladenine37 in tRNA
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