Ligand 1-pyrroline-5-carboxylate

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Basic Ligand Information

Molecular Structure
Picture of 1-pyrroline-5-carboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H7NO2
1-pyrroline-5-carboxylate
DWAKNKKXGALPNW-UHFFFAOYSA-N
Synonyms:
3,4-dihydro-2H-pyrrole-2-carboxylate, DELTA'-Pyrroline-5-carboxylate, DELTA1-Pyrroline-5-carboxylate, DL-delta-1-pyrroline-5-carboxylate, DL-DELTA1-pyrroline 5-carboxylate, DL-pyrroline-5-carboxylate, DL-pyrroline-5-carboxylic acid, pyrroline-5-carboxylate, pyrroline-5-carboxylic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH
show the reaction diagram
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acetyl-CoA + DELTA1-pyrroline-5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-ornithine + 2-oxoglutarate = DELTA1-pyrroline-5-carboxylate + L-glutamate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyrroline-5-carboxylate + NADPH + H+ = ? + NADP+
show the reaction diagram
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1-pyrroline-5-carboxylate + NADH + H+ = L-proline + NAD+
show the reaction diagram
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DELTA1-pyrroline-5-carboxylate + NADPH + H+ = ?
show the reaction diagram
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acetyl-CoA + DELTA1-pyrroline-5-carboxylate + H2O = CoA + N-acetyl-glutamate-gamma-semialdehyde
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
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competitive with respect to L-glutamine
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (11 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
121
-
at pH 7.5 and 30C

KM Value (57 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.4
-
-
7.01
-
at pH 7.5 and 30C
1.4
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.023
-
-

References & Links

Links to other databases for 1-pyrroline-5-carboxylate

ChEBI
PubChem
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PubChem