Ligand ilomastat

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C20H28N4O4
ilomastat
NITYDPDXAAFEIT-DYVFJYSZSA-N
Synonyms:
(2R)-N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide, (2R)-N4-hydroxy-N1-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide, GM6001, GM 6001, N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide

Show all pahtways known for Show all pathways known for ilomastat

Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (43 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
Ilomastat
-
a broad-spectrum MMP inhibitor
-
an MMP inhibitor
-
a broad-spectrum MMP inhibitor
-
significantly reduces Alexa 488-labeled BFT binding
-
a broad-spectrum MMP inhibitor
-

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.002
-
-

IC50 Value (11 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0102
-
pH 8.0, 37°C
0.000317
-
in 25 mM Tris-HCl buffer, pH 9, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C

References & Links

Links to other databases for ilomastat

ChEBI
PubChem
ChEBI
PubChem