Ligand dihydromonacolin L acid
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Basic Ligand Information
Molecular Structure

C19H32O4
dihydromonacolin L acid
NYKUCCPVLWRDEZ-VCWNUMGPSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
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Substrate in Enzyme-catalyzed Reactions (2 results)
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dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
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dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 = monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O
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Product in Enzyme-catalyzed Reactions (1 result)
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dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
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Enzyme Kinetic Parameters
References & Links
Literature References (3)
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Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA
2011
Barriuso, J.; Nguyen, D.T.; Li, J.W.; Roberts, J.N.; MacNevin, G.; Chaytor, J.L.; Marcus, S.L.; Vederas, J.C.; Ro, D.K.
J. Am. Chem. Soc.
133
8078-8081
Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L
1990
Nakamura, T.; Komagata, D.; Murakawa, S.; Sakai, K.; Endo, A.
J. Antibiot.
43
1597-1600
Origin of monacolin L from Aspergillus terreus cultures
1989
Treiber, L.; Reamer, R.; Rooney, C.; Ramjit, H.
J. Antibiot.
42
30-36
Links to other databases for dihydromonacolin L acid