Ligand cardiolipin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure

C₂₅H₄₂O₁₇P₂R₄

cardiolipin

Synonyms:

a cardiolipin, diphosphatidylglycerol, diphosphatidyl glycerol

BRENDA

cardiolipin biosynthesis

KEGG

Glycerophospholipid metabolism

MetaCyc

cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas), cardiolipin biosynthesis I, cardiolipin biosynthesis II, cardiolipin biosynthesis III

Show all BRENDA pathways known for cardiolipin

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

top print hide

2.7.8.41

3 entries

2.7.8.B10

a phosphatidylglycerol + a phosphatidylglycerol = a cardiolipin + glycerol

2.7.8.B11

a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine

Substrate in Enzyme-catalyzed Reactions (10 results)

top print hide

1.11.1.12

glutathione + cardiolipin = ?

394883, 394864

2.1.1.79

S-adenosyl-L-methionine + cardiolipin = S-adenosyl-L-homocysteine + ?

485631

2.3.1.269

cardiolipin + [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine = 1-lyso-cardiolipin + [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine

758353

3.1.1.118

cardiolipin + H2O = ?

761452

3.1.1.32

cardiolipin + H2O = ?

cardiolipin + H2O = phosphatidylglycerophosphate + 1,2-diacylglycerol

135308, 135307

3.1.4.4

cardiolipin + H2O = sn-glycero-1-phosphate + diacylglycerophosphate

135437, 135435

3.1.4.46

cardiolipin + H2O = ?

729721

Product in Enzyme-catalyzed Reactions (13 results)

a phosphatidylglycerol + a phosphatidylethanolamine = a cardiolipin + ethanolamine

Activator in Enzyme-catalyzed Reactions (211 results)

top print hide

1.1.5.3

when functioning with hydrophobic electron acceptor essential in both leaflets of the membrane

287828

1.1.99.3

stimulates in presence of Triton X-100

2.2fold activation at 0.5 mg/ml

10fold stimulation of partially purified enzyme with Escherichia coli cardiolipin

392645

1.7.2.2

cardiolipin liposomes induce nitrite reductase activity of Fe(II)-cytc. The values observed can be compared with the kinetics of the NO2-mediated conversion of other ferrous heme-proteins. Cardiolipins facilitate the NO2-mediated nitrosylation of cytc-Fe(II) in a dose-dependent manner inducing the penta-coordination of the heme-Fe(II) atom

activation of reconstituted mitochondrial enzyme

486378

2.3.1.21

inhibits conversion of palmitoylcarnitine to palmitoyl-CoA, stimulates palmitoylcarnitine formation

236% activation

SIRT5 electrostatically binds to cardiolipin, an N-terminal amphipathic helix mediates SIRT5 binding to cardiolipin, cardiolipin activates desuccinylation of membrane proteins

757175

2.4.1.132

activation, 35% as effective as phosphatidylethanolamine

the activity of MurG is increased in the presence of cardiolipin

stimulation

activation

presence of 1 mM in assay, enhances activity

activation

other phospholipids including phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine and phosphatidylglycerol are not as effective as cardiolipin

activates isozyme PKNalpha

activates

activates, phosphorylation of beta2-AR

stimulates 6fold at 0.36 mM

645346

2.7.8.15

stimulates activity of enzyme in endoplasmic membrane vesicles, due to better solubilization of the dolichol phosphate

stimulates

from bovine liver, activates by 68% at 1 mM

708110

3.4.21.107

enhances DegP proteolytic activity at high temperatures

activates the enzyme with the optimum concentration at 0.04 mg/ml

the hydrolytic activity of CopA is stimulated by phosphoholipid cardiolipin and to some extent by phosphatidylglycerol. The amphipathic platform helix MBC of CopA shows a significant preference for interaction with cardiolipin

binds the co-purified EpsE/cyto-EpsL complex and stimulates its ATPase activity 30-130fold, whereas the activity of EpsE alone is unaffected. Removal of the last 11 residues, residues 243-253, from cyto-EpsL prevents cardiolipin binding as well as stimulation of the ATPase activity of EpsE

686385

Inhibitor in Enzyme-catalyzed Reactions (27 results)

top print hide

1.1.1.25

lower inhibitry potency, about 25% inhibition at 0.0025 mM

740771

1.1.1.27

IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5

667816

1.14.15.4

cardiolipin, dipalmitoyl phasphatidylcholine vesicles, 50% inhibition with 4-5 mol%, complete inhibition at 15 mol%

3 mM, 15% inhibition

noncompetitive vs. NAD+ and NADPH

inhibits conversion of palmitoylcarnitine to palmitoyl-CoA, stimulates palmitoylcarnitine formation

effectiveness of various ligands in protection against inhibition, effect of pH and temperature

inhibitory if included as aqueous sonicated dispersions at 2.5 mg/ml

negatively charged phospholipid, inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction

cardiolipin-containing liposomes specifically inhibit both the proteolytic and ATPase activities of Lon in a dose-dependent manner. Cardiolipin-containing liposomes selectively bind to Lon. The interaction between cardiolipin-containing liposomes and Lon changes with the order of addition of Mg2+/ATP. When cardiolipin-containing liposomes are added after the addition of Mg2+/ATP to Lon, the binding of cardiolipin-containing liposomes to Lon is significantly decreased as compared with the reversed order

717743

3.4.24.23

associates with the enzyme at the cell surface and inhibits by 92%

733838

3.5.1.23

inhibits the ceramide synthesis activity: total inhibition at 2.5-5 mol%, activates the ceramidase activity, mechanism

655998

6.3.4.16

irreversible, inclusion of Mg2+ or MgATP2- in the incubation mixture prevent inactivation

1471

7.4.2.1

ATP-binding subunit HisP with a carboxy-terminal extension of 8 amino acids