Ligand beta-D-galactosyl-1,3-ganglioside GM2

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Basic Ligand Information

Molecular Structure
Picture of beta-D-galactosyl-1,3-ganglioside GM2 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H26N4O8
beta-D-galactosyl-1,3-ganglioside GM2
FMNCPUGORYYCEM-AATLWQCWSA-N
Synonyms:
L-Ala-gamma-D-Glu-Dap, L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate, L-alanyl-gamma-D-glutamyl-meso-diaminopimelate, L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + UDP-N-alpha-D-acetylmuramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
show the reaction diagram
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ATP + L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + UDP-MurNAc = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid + H2O = L-alanyl-gamma-D-glutamic acid + diaminopimelic acid
show the reaction diagram
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ATP + UDP-N-alpha-D-acetylmuramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
show the reaction diagram
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ATP + L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + UDP-MurNAc = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-galactose + ganglioside GM2 = UDP + beta-D-galactosyl-1,3-ganglioside GM2
show the reaction diagram
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.83
-
pH 8.4, 37°C
4.33
-
pH 8.4, temperature not specified in the publication, recombinant His-tagged enzyme

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
pH 8.4, 37°C

References & Links

Links to other databases for beta-D-galactosyl-1,3-ganglioside GM2

ChEBI
PubChem
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PubChem