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Ligand (R)-mevaldehyde Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C5 H1 0 O3
(R)-mevaldehyde
KJLUILOCNALPNM-RXMQYKEDSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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(R)-mevaldehyde + NADPH + H+ = (R)-mevalonate + NADP+
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Enzyme Kinetic Parameters
KM Value (4 results)
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pH 7.3, 37°C, second step of the reaction, mutant enzyme 404D/H398Q with Asp is added at position 404
0.084
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pH 7.3, 37°C, second step of the reaction, mutant enzyme 404N with Asp is added at position 404
0.031
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pH 7.3, 37°C, second step of the reaction, mutant enzyme H398Q
0.1
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pH 7.3, 37°C, second step of the reaction, wild-type enzyme
0.032
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References & Links Literature References (1)
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3-Hydroxy-3-methylglutaryl-coenzyme A reductase of Haloferax volcanii: role of histidine 398 and attenuation of activity by introduction of negative charge at position 404
1997
Bischoff, K.M.; Rodwell, V.W.
Protein Sci.
6
156-161
Links to other databases for (R)-mevaldehyde