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BRENDA support

Ligand hyaluronan

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Basic Ligand Information

Molecular Structure
Picture of hyaluronan (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C56H84N4O45R2
hyaluronan

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hyaluronan + H2O = ?
show the reaction diagram
-
hyaluronan = ?
show the reaction diagram
-
hyaluronan = ?
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
24% inhibition of enzyme SagUGL
-
hyaluronan 800 kDA and 2700 kDa decreased IL1alpha-induced expression of aggrecanase-1 decreased
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
-999
-
kinetic measurement on hyaluronan substrates with sizes ranging from 90 to 752 kDa. kcat: 40.5-42.4/s. A simple and sensitive method is developed for kinetic measurement of recombinant human hyaluronidase PH20 (rHuPH20) on hyaluronan substrates with sizes ranging from 90 to 752 kDa. The method is based on 2-aminobenzamide labeling of hydrolyzed hyaluronan products combined with separation by size exclusion-ultra performance liquid chromatography coupled with fluorescence detection
4.9
-
recombinant enzyme, pH 6.0, 30°C

KM Value (22 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1755
-
-

References & Links

Links to other databases for hyaluronan

ChEBI
PubChem
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