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Ligand tomatine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

6.3.1.9

competitive inhibition versus spermidine, uncompetitive inhibition with respect to ATP and GSH

727114

-

Enzyme Kinetic Parameters

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.1.9

0.0068

-

versus GSH, pH 8.0, 25°C, recombinant enzyme

727114

6.3.1.9

0.0125

-

pH 8.0, 25°C, recombinant enzyme

727114

6.3.1.9

2 entries

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

6.3.1.9

0.018

-

pH 8.0, 25°C, recombinant enzyme

727114

References & Links

Literature References (1)

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Show Reference (1 entry)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

727114

22050226

Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani

2011

Saudagar, P.; Dubey, V.K.

Biol. Chem.

392

1113-1122

Links to other databases for tomatine

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Show Links (1 entry)

ChEBI

PubChem