Ligand XTP

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Basic Ligand Information

Molecular Structure
Picture of XTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H15N4O15P3
XTP
CAEFEWVYEZABLA-UUOKFMHZSA-N
Synonyms:
xanthosine 5'-triphosphate, xanthosine triphosphate
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for XTP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
XTP + H2O = XDP + phosphate
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XTP + H2O = XMP + diphosphate
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xanthosine 5'-triphosphate + H2O = xanthosine 5'-diphosphate + phosphate
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XTP + H2O = XDP + phosphate
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Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
XTP + glycerol = XDP + glycerol 3-phosphate
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XTP + mevalonate = XDP + phosphomevalonate
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XTP + glucose = XDP + D-glucose 6-phosphate
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XTP + CMP = XDP + CDP
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ATP + XTP = diphosphate + ?
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xanthosine triphosphate + L-fucose 1-phosphate = diphosphate + (xanthosine diphosphate)-L-fucose
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GTP + XTP = GppppX + diphosphate
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XTP + dihydrouracil + H2O = ?
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XTP + H2O = ?
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XTP + H2O = XDP + phosphate
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xanthosine 5'-triphosphate + H2O = xanthosine 5'-diphosphate + phosphate
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xanthosine 5'-triphosphate + H2O = xanthosine 5'-monophosphate + diphosphate
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XTP + H2O = XDP + phosphate
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XTP + H2O = XDP + phosphate
show the reaction diagram
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XTP + H2O = XDP + phosphate
show the reaction diagram
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XTP + IMP + L-Asp = XDP + phosphate + adenylosuccinate
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ATP + XTP = P1-(5'-adenosyl),P4-(5'-xanthosyl)tetraphosphate + diphosphate
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
inosine 5'-triphosphate + NAD+ + H2O = xanthosine 5'-triphosphate + NADH
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ATP + XDP = ADP + XTP
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P1,P4-bis(5'-xanthosyl) tetraphosphate + H2O = XTP + XMP
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.05 mM, 50% inhibition
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5 mM, 44% inhibition
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1 mM, 92% inhibition
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in presence of ATP
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22% inhibition at 1 mM
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uncompetitive inhibition of P1,P4-bis(5'-guanosyl)tetraphosphate synthesis
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0.6 mM, 52% inhibition of GTP cyclohydrolase activity
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60% inhibition at 0.5 mM
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basal activity of wild-type enzyme is considerably less sensitive than NO-stimulated wild-type activity
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0.3 mM, about 50% inhibition, inhibition is more pronounced at 37°C compared to 70°C
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.03
-
pH 7.0, 37°C
2625
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25°C, pH 6.75
640
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pH 8.5, 37°C

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.823
-
pH 7.0, 37°C
1.17
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25°C, pH 6.75
0.57
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pH 8.5, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for XTP

ChEBI
PubChem
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PubChem