Ligand 3-phosphoglycerate

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Basic Ligand Information

Molecular Structure
Picture of 3-phosphoglycerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7O7P
3-phosphoglycerate
OSJPPGNTCRNQQC-UHFFFAOYSA-N
Synonyms:
1-glycerate phosphate, 3-glycerate phosphate, 3-phospho-DL-glycerate, 3-Phosphoglyceric acid, glycerate-3-phosphate, Glycerate 3-phosphate, phosphoglycerate, phosphoglyceric acid
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for 3-phosphoglycerate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH
show the reaction diagram
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ATP + 3-phosphoglycerate = ADP + 1,3-bisphosphoglycerate
show the reaction diagram
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3-Phosphoglycerate = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-DL-glycerate + NADPH + H+
show the reaction diagram
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ADP + 1,3-bisphosphoglycerate = ATP + 3-phosphoglycerate
show the reaction diagram
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1,3-diphosphoglyceric acid + (polyphosphate)n = 3-phosphoglycerate + (polyphosphate)n+1
show the reaction diagram
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1,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate
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2-Phosphoglycerate = 3-Phosphoglycerate
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Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycerate 3-phosphate + 2,6-dichlorophenolindophenol = ?
show the reaction diagram
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ATP + 3-phosphoglycerate = ADP + 1,3-bisphosphoglycerate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerol + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = 2,3-dihydroxypropanoic acid + phosphate
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3-phosphoglycerate + H2O = glyceric acid + phosphate
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = ?
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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3-Phosphoglycerate = 2-Phosphoglycerate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phosphohydroxypyruvate + NADH = 3-phosphoglycerate + NAD+
show the reaction diagram
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glyceraldehyde 3-phosphate + NAD+ + H2O = glycerate 3-phosphate + NADH
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glyceralaldehyde-3-phosphate + NAD+ + H2O = glycerate-3-phosphate + NADH
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ATP + D-glycerate = ADP + 3-phosphoglycerate
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ADP + 1,3-bisphosphoglycerate = ATP + 3-phosphoglycerate
show the reaction diagram
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1,3-diphosphoglyceric acid + (polyphosphate)n = 3-phosphoglycerate + (polyphosphate)n+1
show the reaction diagram
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2-Phosphoglycerate = 3-Phosphoglycerate
show the reaction diagram
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2-Phosphoglycerate = 3-Phosphoglycerate
show the reaction diagram
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Glucose 1-phosphate + 1,3-bisphosphoglycerate = Glucose 1,6-diphosphate + glycerate 3-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (66 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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slightly activation
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stimulates
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activation of autocatalytical flavinylation
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10 mM, activates
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activates
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slight activation
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slight activation
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50 mM, 5fold activation of muscle alpha-amylase
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required, can be substituted by 2-phosphoglycerate
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Inhibitor in Enzyme-catalyzed Reactions (57 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive inhibition
-
about 40% residual activity at 5 mM
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noncompetitive
-
74% inhibition at 6 mM and pH 7.2
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inhibits at higher concentrations; inhibits at higher concentrations; inhibits at higher concentrations; inhibits at higher concentrations; inhibits at higher concentrations; inhibits at higher concentrations
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66% inhibition at 20 mM
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inhibits uridylyl removing activity
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no inhibition of UDP-glucose synthesis
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weak competetive inhibitor
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alpha-acetolactate synthetase and alpha-acetolactate decarboxylase are measured together
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uncompetitive inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (78 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (35 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.212
-
pH 9.0
1.21
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25°C, pH 5.6

Ki Value (15 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
12.7
-
at pH 7.5 and 37°C
0.084
-
pH 7.8, 25°C
0.25
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pH 7.5

References & Links

Links to other databases for 3-phosphoglycerate

ChEBI
PubChem
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PubChem