Ligand Selenite

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of Selenite (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2O3Se
Selenite
MCAHWIHFGHIESP-UHFFFAOYSA-L
Synonyms:
(SeO3)2-, SeO32-
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
selenite + NADH + H+ = selenium + H2O + NAD+
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(SeO3)2- + H2 + ? = Se + H2O + ?
show the reaction diagram
-
selenite + ferricyanide + H2O = ? + ferrocyanide
show the reaction diagram
-
SeO32- + a [DsrC protein]-dithiol + 2 reduced methyl viologen + 2 H+ = HSe- + a [DsrC protein]-disulfide + 2 oxidized methyl viologen + 3 H2O
show the reaction diagram
-
selenite + NADH + H+ = selenium + H2O + NAD+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
selenate + reduced methylviologen = selenite + H2O + oxidized methylviologen
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
4fold increase in activity in U-1256 cells, less pronounced in presence of doxorubicin, differences between drug-sensitive and drug-resistant cells, overview
-

Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inactivates IDPm
-
20% inhibition at 0.1 mg/l
-
selenite induces topoisomerase I-DNA complexes in K562 cells
-
selenite induces topoisomerase II-DNA complexes in K562 cells
-
competitively inhibits phosphate uptake; competitively inhibits phosphate uptake; competitively inhibits phosphate uptake; competitively inhibits phosphate uptake
-

Metals and Ions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
selenium treatment results in increased expression of almost all TrxR1 mRNA variants with increasing concentrations of selenite
-
one of the activating anions, that stimulates MgATPase activity of EcF1, likely due to a decrease in a relative content of MgADP-inhibited EcF1 because activating anions accelerate reactivation of MgADP-inhibited enzyme
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
5.47
-
pH 6.0, 35°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Selenite

ChEBI
PubChem
-
PubChem