Ligand N1-acetylspermidine

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Basic Ligand Information

Molecular Structure
Picture of N1-acetylspermidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H21N3O
N1-acetylspermidine
MQTAVJHICJWXBR-UHFFFAOYSA-N
Synonyms:
1-N-acetylspermidine, acetylspermidine, monoacetylspermidine, N1-acetyl-spermidine
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for N1-acetylspermidine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2
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N1-acetylspermidine + H2O = acetate + spermidine
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N1-acetylspermidine + H2O = acetate + spermidine
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamidopropanal + H2O2
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acetyl-CoA + spermidine = CoA + N1-acetylspermidine
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Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N1-acetylspermidine + O2 + H2O = ?
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N1-acetyl-spermidine + H2O + O2 = ?
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monoacetylspermidine + electron acceptor = ? + reduced electron acceptor
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acetyl-CoA + N1-acetylspermidine = CoA + N1,N8-diacetylspermidine
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acetylspermidine + H2O = acetate + spermidine
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N1-acetylspermidine + H2O = acetate + spermidine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamidopropanal + H2O2
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N1-acetylspermine + O2 + H2O = N1-acetylspermidine + 3-aminopropanal + H2O2
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
60% of activation by putrescine
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, less than 50% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
684
-
pH 9.0, 20°C

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.625
-
-
0.066
-
pH 9.0, 20°C
4.4
-
-
0.003
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.37
-
-

References & Links

Links to other databases for N1-acetylspermidine

ChEBI
PubChem
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PubChem