Ligand D-valine

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Basic Ligand Information

Molecular Structure
Picture of D-valine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO2
D-valine
KZSNJWFQEVHDMF-SCSAIBSYSA-N
Synonyms:
D-Val

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + D-valine = CoA + N-acetyl-D-valine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-valine + oxidized 2,6-dichloroindophenol + H2O = 2-oxoisopentanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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acetyl-CoA + D-valine = CoA + N-acetyl-D-valine
show the reaction diagram
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D-valine + 2-oxoadipate = 3-methyl-2-oxobutanoate + 2-aminoadipate
show the reaction diagram
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D-valine = L-Val
show the reaction diagram
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ATP + D-Val = ADP + phosphate + D-Val-D-Val
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxo-3-methylbutyric acid + NH3 + NADPH + H+ = D-valine + H2O + NADP+
show the reaction diagram
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D-alanine + 2-oxoisovalerate = pyruvate + D-valine
show the reaction diagram
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N-carbamoyl-D-Val + H2O = D-Val + NH3 + CO2
show the reaction diagram
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L-valine = D-valine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enhances activity at concentrations below 50 mM
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activation of isoforms prolidase I and prolidase II
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, 11% inhibition
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5 mM, 16% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (10 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (18 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.78
-
pH 8.7, 37°C

KM Value (24 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.01
-
pH 8.7, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10.8
-
inhibition of deamination of D-Leu

References & Links

Links to other databases for D-valine

ChEBI
PubChem
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PubChem