Ligand Acrylamide

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Basic Ligand Information

Molecular Structure
Picture of Acrylamide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H5NO
Acrylamide
RRNKCSIEGPOIKI-UHFFFAOYSA-N
Synonyms:
2-Propenoic acid amide, prop-2-enamide


Show all pahtways known for Show all BRENDA pathways known for Acrylamide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acrylonitrile + H2O = acrylamide
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acrylamide + H2O = acrylic acid + NH3
show the reaction diagram
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acrylamide + H2O = acrylic acid + NH3
show the reaction diagram
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prop-2-enamide + H2O = ?
show the reaction diagram
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acrylamide + H2O = acrylic acid + NH3
show the reaction diagram
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acrylamide + H2O = ?
show the reaction diagram
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acrylamide + H2O = acrylonitrile
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acrylonitrile + H2O = acrylamide
show the reaction diagram
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-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
kinesin inhibition is observed at acrylamide concentrations as low as 0.1 mM
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acrylamide is a catalytic inhibitor, no enzyme poison, it antagonizes the effect of etoposide, a topoisomerase II poison, and inhibits the enzyme in vivo in V-79 cells. Acrylamide reduces the level of catalytically active cellular topoisomerase II available for the action of etoposide. Assay in presence of DTT
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3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Acrylamide

ChEBI
PubChem
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PubChem