Ligand 7alpha-hydroxydehydroepiandrosterone

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Basic Ligand Information

Molecular Structure
Picture of 7alpha-hydroxydehydroepiandrosterone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H28O3
7alpha-hydroxydehydroepiandrosterone
OLPSAOWBSPXZEA-JIEICEMKSA-N
Synonyms:
3beta,7alpha-dihydroxy-5-androsten-17-one, 7alpha-hydroxy-dehydroepiandrosterone
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dehydroepiandrosterone + NADPH + H+ + O2 = 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7alpha-hydroxydehydroepiandrosterone + NADP+ = 7beta-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH
show the reaction diagram
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7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+ = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive type inhibition of cortisol oxidation
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.043
-
at pH 7.4 and 37C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0029
-
at pH 7.4 and 37C

References & Links

Links to other databases for 7alpha-hydroxydehydroepiandrosterone

ChEBI
PubChem
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PubChem