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Ligand MnATP2-

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.6.1.1

MnATP2- = ?

34805, 34763

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.6.1

Mn-ATP2- + D-ribose 5-phosphate = Mn-AMP + 5-phospho-alpha-D-ribose 1-diphosphate

723524

-

4.6.1.1

MnATP2- = ?

34805, 34763, 34778

-

Enzyme Cofactor/Cosubstrate (1 result)

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Show Cofactor (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.11.1

-

694132

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.2.2.4

-

171830, 171831

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.4.1

at high concentrations, above 0.6 mM, activating below

645112

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

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Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.6.1

45.1

-

in the presence of 5 mM Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C

723524

2.7.6.1

46.3

-

in the absence of free Mg2+ or Mn2+, in 50 mM potassium phosphate pH 8.0, at 37°C

723524

2.7.6.1

2 entries

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.5.2.9

0.5

-

-

209379

4.6.1.1

0.067

-

-

34763

4.6.1.1

0.086

-

-

34778

4.6.1.1

2 entries

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

34763

-

Adenylate cyclase in cilia from Paramecium

1983

Schultz, J.E.; Klumpp, S.

FEBS Lett.

154

347-350

34778

104981

Adenylate cyclase in silkworm. Properties of the enzyme in pupal fat body

1978

Morishima, I.

J. Biochem.

84

1495-1500

34805

8702736

Soluble adenylyl cyclase from Spodoptera frugiperda (Sf9) cells. Purification and biochemical characterization

1996

Kawabe, J.I.; Toya, Y.; Schencke, C.; Oka, N.; Ebina, T.; Ishikawa, Y.

J. Biol. Chem.

271

20132-20137

171830

6251048

Evidence for substantial separation of the catalytic and allosteric sites of AMP nucleosidase

1980

De Wolf Jr., W.E.; Markham, G.D.; Schramm, V.L.

J. Biol. Chem.

255

8210-8215

171831

-

Interaction of Mn2+ and MnATP2- with the allosteric sites of AMP nucleosidase

1980

Schramm, V.L.; Reed, G.H.

J. Biol. Chem.

255

5795-5801

209379

16660609

5-Oxoprolinase (L-pyroglutamate hydrolase) in higher plants

1978

Mazelis, M.; Creveling, R.G.

Plant Physiol.

62

798-801

645112

168307

Purification and characterization of a polyphosphate kinase from Arthrobacter atrocyaneus

1975

Levinson, S.L.; Jacobs, L.H.; Krulwich, T.A.; Li, H.C.

J. Gen. Microbiol.

88

65-74

694132

18270660

The sole serine/threonine protein kinase and its cognate phosphatase from Aquifex aeolicus targets pyrimidine biosynthesis

2008

Purcarea, C.; Fernando, R.; Evans, H.G.; Evans, D.R.

Mol. Cell. Biochem.

311

199-213

723524

21085589

Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis

2010

Lucarelli, A.P.; Buroni, S.; Pasca, M.R.; Rizzi, M.; Cavagnino, A.; Valentini, G.; Riccardi, G.; Chiarelli, L.R.

PLoS ONE

5

e15494

Links to other databases for MnATP2-

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Show Links (1 entry)