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Ligand single-stranded DNA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

KEGG

Amyotrophic lateral sclerosis, beta-Lactam resistance, Gastric cancer, Hepatocellular carcinoma, Neutrophil extracellular trap formation, Pathways in cancer, Purine metabolism, Pyrimidine metabolism more

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (23 results)

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Show Natural Substrate (23 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.101

ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate

760945, 761889, 760348, 760349, 760416, 762458, 760588, 760314, 760530

-

2.7.7.102

ssDNA + n dNTP = ssDNA/pppdN(pdN)n-1 hybrid + (n-1) diphosphate

760821

-

2.7.7.31

ssDNA + ferrocene-labeled dideoxy-UTP = ssDNA-ddUFc + diphosphate

674205

-

3.1.11.1

ssDNA + H2O = ?

750362, 710152

-

3.1.11.3

single-stranded DNA + H2O = 5'-phosphomononucleotides

133989, 133983, 133984

-

3.1.11.4

single-stranded DNA + H2O = ?

94464, 94465

-

3.1.11.5

single stranded DNA + H2O = 5'-phosphomonoester oligonucleotides

133995, 134022, 134016, 134023, 134031, 134019, 134020, 134026, 134030, 133996, 134002, 134029

-

3.1.11.6

single-stranded DNA + H2O = hydrolyzed single-stranded DNA

134035, 134036, 134037, 134038

-

3.1.21.1

ssDNA + H2O = 5'-phosphodinucleotide + 5'-phosphooligonucleotide

651509

-

3.1.21.2

single-stranded DNA + H2O = 5'-phosphooligonucleotides

134240, 682183

-

3.1.30.1

ssDNA + H2O = fragments of ssDNA

655322, 655642, 655944, 655943, 655945

-

3.1.30.2

ssDNA + H2O = ?

678425, 666651

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1906, 1907, 1909, 1945, 1951, 1956, 1914, 1966, 1952

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n

651934, 652140, 652248, 652322, 653285, 653370, 653491, 651783, 650937, 652785, 662058, 651145, 651216, 653371, 653066, 651669, 653383, 651161, 651883, 651206, 653386, 652402, 650859, 653374, 662411, 661615, 661829, 662938, 661572

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

707630, 708312, 709931, 676220, 707895, 709144, 706974, 673070, 725026, 662211, 662314, 676224, 676060, 673276, 676260, 673278, 671889, 672249, 676211, 673331

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n

662058

-

6.5.1.2

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

676060

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1909, 1974, 1910, 1979

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

707538, 707630

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m

671030, 651683, 651212, 650937, 651073, 652360, 652463, 652489, 653376, 653388, 653853, 652786, 653923, 649250, 649444, 652175, 650967, 653379, 662211, 671380

-

6.5.1.7

ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m

692105, 727438

-

6.5.1.7

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

692105, 727438

-

6.5.1.7

GTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = GMP + diphosphate + (deoxyribonucleotide)n+m

692105, 727438

-

6.5.1.1

4 entries

6.5.1.2

4 entries

6.5.1.7

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.11.3

double-stranded DNA + H2O = single-stranded DNA + 5'-phospho-2'-deoxynucleotides

-

-

3.1.11.5

double-stranded DNA = single-stranded DNA

653336

-

3.1.26.4

DNA-RNA hybrid + H2O = ssDNA + 5'-phosphomonoester oligonucleotides

-

-

Substrate in Enzyme-catalyzed Reactions (57 results)

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Show Substrate (57 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.101

ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate

750951, 760945, 761889, 760348, 760349, 760416, 762458, 760588, 760314, 760530

-

2.7.7.102

ssDNA + n dNTP = ssDNA/pppdN(pdN)n-1 hybrid + (n-1) diphosphate

760821

-

2.7.7.31

ssDNA + ferrocene-labeled dideoxy-UTP = ssDNA-ddUFc + diphosphate

674205

-

3.1.11.1

single-stranded DNA + H2O = ?

707503, 653308, 725357

-

3.1.11.1

ssDNA + H2O = ?

700988, 750362, 710152, 719519

-

3.1.11.1

2 entries

3.1.11.3

single-stranded DNA + H2O = 5'-phosphomononucleotides

133989, 133984, 133983, 133990

-

3.1.11.4

single-stranded DNA + H2O = ?

94464, 94465

-

3.1.11.4

single-stranded DNA + H2O = dinucleotide + trinucleotide

94465

-

3.1.11.4

2 entries

3.1.11.5

single stranded DNA + H2O = 5'-phosphomonoester oligonucleotides

133995, 134022, 134016, 134023, 134031, 134019, 134020, 134026, 134030, 133996, 134002, 134029

-

3.1.11.6

single-stranded DNA + H2O = ?

698618, 700496

-

3.1.11.6

single-stranded DNA + H2O = hydrolyzed single-stranded DNA

134039, 134040, 134041, 134042, 134043, 134044, 134045, 134046, 134048, 680517, 682560, 707510, 134047, 134035, 134036, 134037, 134038

-

3.1.11.6

2 entries

3.1.12.1

ssDNA + H2O = nucleoside 3'-phosphate + ?

725211, 726307

-

3.1.21.1

single-stranded DNA + H2O = 5'-phosphooligonucleotides + ?

666780

-

3.1.21.1

single-stranded DNA + H2O = ?

665370

-

3.1.21.1

ssDNA + H2O = 5'-phosphodinucleotide + 5'-phosphooligonucleotide

653014, 651509

-

3.1.21.1

ssDNA + H2O = ?

651077

-

3.1.21.2

single-stranded DNA + H2O = 5'-phosphooligonucleotides

134240, 682183, 682168, 682182

-

3.1.21.2

single-stranded DNA + H2O = ?

749574

-

3.1.21.1

4 entries

3.1.21.2

2 entries

3.1.21.7

single-stranded DNA + H2O = ?

752179

-

3.1.22.1

ssDNA + H2O = oligonucleotides + ?

679323

-

3.1.3.32

DNA with 3'-phosphate ends + H2O = DNA + phosphate

81073

-

3.1.30.1

ssDNA + H2O = 5'-phosphomononucleotides + 5'-phosphooligonucleotides

134969, 134973, 134987, 134971, 134997, 134990, 135004, 134989, 134984, 134986, 95076, 134992, 134999, 664417, 134998, 134962, 134966, 134967, 134972, 134974, 134975, 134976, 134977, 134978, 134979, 134981, 134982, 134983, 135000, 135001, 135002, 134988, 134996, 134960, 134991, 134994, 134959, 134961, 134968

-

3.1.30.1

ssDNA + H2O = fragments of ssDNA

655322, 655642, 655944, 655943, 655945, 655989

-

3.1.30.1

2 entries

3.1.30.2

ssDNA + H2O = ?

678425, 657122, 666651

-

3.1.31.1

ss-DNA + H2O = ?

678227

-

3.1.31.1

ssDNA + H2O = ?

682777

-

3.1.31.1

2 entries

3.2.2.22

single-stranded DNA + H2O = ?

665550

-

3.6.1.15

ssDNA + H2O = ?

667694

-

6.5.1.1

5'-O-(3-Thio)adenosine triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m = 5'-O-(3-Thio)adenosine monophosphate + diphosphate + (deoxyribonucleotide)n+m

1913

-

6.5.1.1

adenosine 5'-[alpha-thio]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

710155

-

6.5.1.1

adenosine 5'-[beta,gamma-imido]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

710155

-

6.5.1.1

adenosine 5'-[gamma-thio]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

710155

-

6.5.1.1

ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m

727504

-

6.5.1.1

AMP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

710155

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1906, 1907, 1909, 1945, 1951, 1956, 1914, 1966, 1952

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)m+n

716669, 650859, 651206, 651883, 651934, 652140, 652248, 652322, 653285, 653370, 653386, 691611, 691966, 693028, 694437, 694449, 694470, 695255, 653491, 716296, 661207, 691203, 695166, 716677, 651783, 650937, 652785, 694991, 662058, 651145, 651216, 653371, 694899, 715619, 653374, 653066, 651669, 653383, 716396, 694908, 716154, 692459, 693561, 652402, 651161, 662411, 661615, 661829, 662938, 661572, 662434, 663223, 662656, 693984, 694906, 690511, 690851, 715620

-

6.5.1.1

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

1923, 1907, 1914, 1964, 707630, 1909, 1910, 710155, 1917, 1966, 1922, 1928, 1935, 1939, 1940, 1941, 1942, 1944, 1949, 1951, 1952, 1953, 1954, 1958, 1959, 1960, 692315, 694087, 708312, 709055, 709931, 709932, 1912, 1925, 1945, 1956, 676220, 1915, 1920, 1929, 707895, 709144, 1963, 1921, 1936, 1946, 1947, 690421, 707116, 707384, 710593, 1931, 1948, 1918, 1950, 1955, 1911, 709023, 709534, 706970, 706974, 673070, 725026, 727917, 1962, 1961, 1938, 1932, 1906, 1937, 1913, 1934, 1943, 1933, 1930, 1957, 1916, 1965, 1908, 1926, 1927, 1924, 1919, 662211, 662314, 661428, 676224, 676060, 673276, 676260, 673278, 671889, 672249, 676211, 673331, 672236, 675877, 722648, 726420, 728739, 727896, 727504

-

6.5.1.1

ATPalphaS + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1962

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n

662058, 651216, 653383

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)n+m

1906, 1909, 1918

-

6.5.1.2

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

676060

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1909, 1974, 1910, 1979

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

707538, 708959, 707130, 707630, 709023, 706961

-

6.5.1.2

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + nicotinamide nucleotide + (deoxyribonucleotide)n+m

1909, 651683, 713771, 715672, 651212, 650937, 1979, 1976, 1977, 651073, 652360, 652463, 652489, 653376, 653388, 653853, 662343, 690421, 690424, 693984, 715971, 716944, 652786, 653923, 692315, 662211, 1978, 1981, 671030, 694991, 649250, 649444, 652175, 650967, 693115, 677062, 693979, 1974, 1971, 1975, 1969, 1972, 1910, 1970, 1980, 653379, 660985, 662744, 661248, 671380, 691966, 714854

-

6.5.1.2

NADH + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1909

-

6.5.1.2

Thionicotinamide derivative of NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = ?

1909

-

6.5.1.3

(deoxyribonucleotide)n = circular (deoxyribonucleotide)n

694452

-

6.5.1.3

ATP + (deoxyribonucleotide)n = adenylyl-(deoxyribonucleotide)n + diphosphate

694452

-

6.5.1.6

ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m

672745

-

6.5.1.6

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

661788, 672745

-

6.5.1.6

GTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = GMP + diphosphate + (deoxyribonucleotide)n+m

672745

-

6.5.1.6

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

661788, 672745

-

6.5.1.6

TTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = TMP + diphosphate + (deoxyribonucleotide)n+m

672745

-

6.5.1.6

UTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = UMP + diphosphate + (deoxyribonucleotide)n+m

672745

-

6.5.1.7

ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + phosphate + (deoxyribonucleotide)n+m

692105, 727438

-

6.5.1.7

ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

727438, 692105

-

6.5.1.7

GTP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = GMP + diphosphate + (deoxyribonucleotide)n+m

692105, 727438

-

6.5.1.1

12 entries

6.5.1.2

6 entries

6.5.1.3

2 entries

6.5.1.6

6 entries

6.5.1.7

3 entries

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.11.3

double-stranded DNA + H2O = single-stranded DNA + 5'-phospho-2'-deoxynucleotides

-

-

3.1.11.5

double-stranded DNA = single-stranded DNA

653336

-

3.1.21.7

49-mer oligonucleotide + H2O = 3-alpha,beta-unsaturated aldehyde + 3'-phosphate DNA-termini

288777

-

3.1.26.4

DNA-RNA hybrid + H2O = ssDNA + 5'-phosphomonoester oligonucleotides

-

-

3.1.3.32

DNA with 5'-hydroxyl ends + ATP = DNA with 5'-phosphate ends + ADP

81073

-

5.6.2.3

double-stranded DNA = single-stranded DNA

-

-

Activator in Enzyme-catalyzed Reactions (29 results)

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Show Activating Compound (29 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.5.1

-

135504

-

3.1.5.1

Dgt preparations lacking DNA are able to bind single-stranded DNA with high affinity. DNA binding positively affects the activity of the enzyme. dGTPase activity displays sigmoidal (cooperative) behavior without DNA but hyperbolic (Michaelis-Menten) kinetics in its presence, consistent with a specific lowering of the apparent Km for dGTP

751041

-

3.1.5.1

2 entries

3.4.21.53

ATP and protein hydrolysis

29360

-

3.4.21.88

RecA protein and single-stranded DNA are required for activity being attributed to a Ser/Lys dyad. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair

29801

-

3.6.1.39

the presence of single-stranded DNA stimulates the rate of dTTP hydrolysis about 100fold in the case of wild type enzyme

719939

-

3.6.4.13

on single-stranded RNA binding, the NS3 enzyme switches to a catalytic competent state imparted by an inward movement of the P-loop, interdomain closure and a change in the divalent metal coordination shell, providing a structural basis for RNA-stimulated ATP hydrolysis

692072

-

3.6.4.13

the ATPase activity is stimulated by the presence of RNA and single-stranded DNA molecules

701395

-

3.6.4.13

weak stimulation

694539

-

3.6.4.B7

ssDNA, like RecA, RadA's ATPase activity is strongly stimulated by ssDNA

756571

-

3.6.4.B7

at 75°C, all DNAs tested stimulated ATPase activity of the RadA. The ssDNA-dependent ATPase activity of displays a temperature-dependent capacity to exist in two different catalytic modes, with 75°C being the critical threshold temperature

724905

-

3.6.4.B7

ATPase activity of RadA is drastically stimulated by ssDNA and to a lesser extent by dsDNA. The activity increases linearly with ssDNA concentration until a saturation plateau, at which the apparent binding stoichiometry is 3 nucleotides for 1 RadA

725340

-

3.6.4.B7

the RadA protein is a ssDNA-dependent ATPase

725102

-

3.6.4.13

3 entries

3.6.4.B7

4 entries

3.6.4.B8

the MacRFC complex (a protein complex of Mac-RFCS1, MacRFCS2, and MacRFCL) possesses very low intrinsic ATPase activity. This activity is stimulated about 33fold by ssDNA

725368

-

5.6.2.3

more than 5fold stimulation of ATPase activity

694417

-

5.6.2.3

nonstructural single-stranded DNA greatly stimulates ATPase activity due to a high affinity for PIF1, even though PIF1 preferentially unwinds forked substrates. The N-terminal portion oF PIF1 helicase, named the PIF1 N-terminal (PINT) domain, contributes to enhancing the interaction with single-stranded DNA through intrinsic binding activity

694453

-

5.6.2.3

stimulates

692493, 692824

-

5.6.2.3

stimulates activity

690869

-

5.6.2.3

activates the ATPase activity of the enzyme

733932

-

5.6.2.3

ATPase activity of StoHerA is stimulated by ssDNA and dsDNA

724822

-

5.6.2.3

stimulates ATPase activity

692828

-

5.6.2.3

the ATPase activity of enzyme DnaB is stimulated in the presence of ssDNA

733833

-

5.6.2.4

MER3 ATPase activity is stimulated by either single- or double-stranded DNA

692955

-

5.6.2.4

required

692155

-

5.6.2.4

stimulates

692824

-

5.6.2.4

stimulates activity

694469

-

5.6.2.4

the enzyme is strongly stimulated by either single- or double-stranded DNA

692938

-

5.6.2.4

the enzyme requires single-stranded DNA for activation

692979

-

5.6.2.4

ATPase activity of StoHerA is stimulated by ssDNA and dsDNA

724822

-

5.6.2.4

stimulates ATPase activity

692828

-

5.6.2.3

8 entries

5.6.2.4

8 entries

Inhibitor in Enzyme-catalyzed Reactions (14 results)

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Show Inhibitors (14 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.7

-

643598

-

2.7.7.7

inhibition of polymerase alpha, competitive with respect to activated DNA substrate

643588

-

2.7.7.7

2 entries

3.1.22.5

-

646292

-

3.1.30.2

-

677620

-

5.6.2.1

-

3802, 3824

-

5.6.2.1

heat-denatured single-stranded DNA

3814

-

5.6.2.1

strong inhibitor of relaxation reaction

3813

-

5.6.2.1

3 entries

5.6.2.2

strong inhibition of relaxation

3813

-

5.6.2.3

ATPase activity is slightly stimulated by ssDNA, and only M13mp19 ssDNA stimulats it significantly

692898

-

5.6.2.3

the ssDNA annealing activity opposes the dsDNA unwinding activity of human mtDNA helicase in the absence of an SSB or a ssDNA trap, and only ssDNA but not dsDNA serves as a competitive inhibitor of annealing activity even though the helicase is shown to bind dsDNA

756521

-

5.6.2.3

the ssDNA annealing activity opposes the dsDNA unwinding activity of mtDNA helicase in the absence of an SSB or a ssDNA trap, and only ssDNA but not dsDNA serves as a competitive inhibitor of annealing activity even though the helicase is shown to bind dsDNA

756521

-

5.6.2.4

-

692262

-

5.6.2.4

0.01 mM

692150

-

5.6.2.3

3 entries

5.6.2.4

2 entries

6.4.1.2

inhibits the reaction catalyzed by carboxyltransferase in a competitive manner with respect to both malonyl-CoA and biocytin. DNA and heparin can also bind to the enzyme simultaneously, but the binding of either molecule has a strong synergistic effect on binding of the other, binding structure and inhibition mechanism, overview

695014

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (7 results)

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Show Turnover Number (7 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.11.1

115.5

-

at 37°C, in 20 mM Tris-HCl buffer, pH 8.0, 100 mM NaCl, 3 mM MgCl2, 1 mM 2-mercaptoethanol, 0.1 g/l bovine serum albumin, 10% (v/v) glycerol, 5% (v/v) dimethyl sulfoxide

707503

6.5.1.1

0.025

-

mutant enzyme E143L

694908

6.5.1.1

0.048

-

mutant enzyme T491S

694908

6.5.1.1

0.05

-

mutant enzyme D162E

694908

6.5.1.1

0.051

-

mutant enzyme A576P

694908

6.5.1.1

0.051

-

mutant enzyme N255G

694908

6.5.1.1

0.056

-

wild type enzyme

694908

6.5.1.1

6 entries

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.11.1

0.016

-

at 37°C, in 20 mM Tris-HCl buffer, pH 8.0, 100 mM NaCl, 3 mM MgCl2, 1 mM 2-mercaptoethanol, 0.1 g/l bovine serum albumin, 10% (v/v) glycerol, 5% (v/v) dimethyl sulfoxide

707503

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.4.1.2

0.0342

-

versus biocytin

695014

6.4.1.2

0.085

-

versus malonyl-CoA

695014

6.4.1.2

2 entries

References & Links

Literature References (377)

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Show Reference (377 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1906

1497311

Mammalian DNA ligases

1992

Lindahl, T.; Barnes, D.E.

Annu. Rev. Biochem.

61

251-281

1907

9363683

Mammalian DNA ligases

1997

Tomkinson, A.E.; Levin, D.S.

BioEssays

19

893-901

1908

2204827

Eukaryotic DNA ligases

1990

Lasko, D.D.; Tomkinson, A.E.; Lindahl, T.

Mutat. Res.

236

277-287

1909

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DNA ligases

1982

Engler, M.J.; Richardson, C.C.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

15

3-29

1910

19082974

DNA and RNA ligases (EC 6.5.1.1, EC 6.5.1.2, and EC 6.5.1.3)

1993

Maunders, M.J.

Methods Mol. Biol.

16

213-230

1911

3935108

Variation in DNA ligase structure during repair and replication processes in monkey kidney cells

1985

Mezzina, M.; Franchi, E.; Izzo, R.; Bertazzoni, U.; Rossignol, J.M.; Sarasin, A.

Biochem. Biophys. Res. Commun.

132

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1912

3803389

Mammalia DNA ligase. Structure and function in rat-liver tissues

1987

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Eur. J. Biochem.

162

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1913

3115985

DNA ligase from Drosophila melanogaster embryos. Substrate specificity and mechanism of action

1987

Rabin, B.A.; Chase, J.W.

J. Biol. Chem.

262

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1914

3090038

DNA ligase from Drosophila melanogaster embryos. Purification and physical characterization

1986

Rabin, B.A.; Hawley, R.S.; Chase, J.W.

J. Biol. Chem.

261

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1915

3084491

Purification of DNA ligase II from calf thymus and preparation of rabbit antibody against calf thymus DNA ligase II

1986

Teraoka, H.; Sumikawa, T.; Tsukada, K.

J. Biol. Chem.

261

6888-6892

1916

2987879

Influence of monovalent cations on the activity of T4 DNA ligase in the presence of polyethylene glycol

1985

Hayashi, K.; Nakazawa, M.; Ishizaki, Y.; Obayashi, A.

Nucleic Acids Res.

13

3261-3271

1917

6746618

DNA ligase from mouse Ehrlich ascites tumor cells

1984

Teraoka, H.; Sawai, M.; Tsukada, K.

J. Biochem.

95

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1918

6746596

Purification and properties of a DNA ligase from sea urchin embryos

1984

Oishi, N.; Shimada, H.

J. Biochem.

95

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1919

6279395

Temperature dependence of the activity of DNA-modifying enzymes: endonucleases and DNA ligase

1982

Pohl, F.M.; Thomae, R.; Karst, A.

Eur. J. Biochem.

123

141-152

1920

6802840

Eukaryotic DNA ligase. Purification and properties of the enzyme from bovine thymus and immunochemical studies of the enzyme from animal tissues

1982

Terakoa, H.; Tsukada, K.

J. Biol. Chem.

257

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1921

6269089

Specific and reversible inhibition of the blunt end joining activity of the T4 DNA ligase

1981

Ferretti, L.; Sgaramella, V.

Nucleic Acids Res.

9

3695-3705

1922

7357002

Purification and properties of a DNA ligase from a soluble DNA replication complex

1980

Tsuruo, T.; Arens, M.; Padmanabhan, R.; Green, M.

Biochim. Biophys. Acta

606

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1923

29616

Low molecular weight DNA ligase of chick embryo

1978

Katouzian, M.; David, J.C.

Biochem. Biophys. Res. Commun.

82

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1924

791000

Purification and electrophoretic assay of T4-induced polynucleotide ligase for the in vitro construction of recombinant DNA molecules

1976

Moore, S.K.; James, E.

Anal. Biochem.

75

545-554

1925

1267800

A DNA ligase from mitochondria of rat liver

1976

Levin, C.J.; Zimmerman, S.B.

Biochem. Biophys. Res. Commun.

69

514-520

1926

4204425

Two forms of the DNA ligase of human cells

1973

Pedrali Noy, G.C.F.; Spadari, S; Ciarrocchi, G.; Pedrini, A.M.; Falaschi, A.

Eur. J. Biochem.

39

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1927

4738719

Two DNA ligase activities from calf thymus

1973

Söderhäll, S.; Lindahl, T.

Biochem. Biophys. Res. Commun.

53

910-916

1928

6651829

DNA ligase activity in crude extracts of fibroblasts and lymphocytes

1983

Saucier, J.M.; Laval, F.

Biochem. Biophys. Res. Commun.

116

657-662

1929

6882774

Kinetic studies on the reaction catalyzed by DNA ligase from calf thymus

1983

Teraoka, H.; Sawai, M.; Tsukada, K.

Biochim. Biophys. Acta

747

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1930

1508676

Purification and characterization of DNA ligase I from the trypanosomatid Crithidia fasciculata

1992

Brown, G.W.; Ray, D.S.

Nucleic Acids Res.

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1931

8653795

Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7

1996

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Cell

85

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1932

8519771

Vaccinia virus DNA ligase: specificity, fidelity, and inhibition

1995

Shuman, S.

Biochemistry

34

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1933

9220997

Ligation of RNA-containing duplex by vaccinia DNA ligase

1997

Sekiguchi, J.; Shuman, S.

Biochemistry

36

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1934

8805556

Closing the gap on DNA ligase

1996

Shuman, S.

Structure

4

653-656

1935

8466479

Biochemical characterization of a protein inhibitor for DNA ligase I from human cells

1993

Yang, S.; Becker, F.F.; Chan, J.Y.H.

Biochem. Biophys. Res. Commun.

191

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1936

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Functional characterization of the T4 DNA ligase: a new insight into the mechanism of action

1997

Rossi, R.; Montecucco, A.; Ciarrocchi, G.; Biamonti, G.

Nucleic Acids Res.

25

2106-2113

1937

9060431

Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae

1997

Cheng, C.; Shuman, S.

Nucleic Acids Res.

25

1369-1374

1938

9164481

The identification and purification of a novel mammalian DNA ligase

1997

Johnson, A.P.; Fairman, M.P.

Mutat. Res.

383

205-212

1939

8471077

Lack of discrimination between DNA ligase I and III by two classes of inhibitors, anthracyclines and distamycin

1993

Montecucco, A.; Lestingi, M.; Rossignol, J.M.; Elder, R.H.; Ciarrocchi, G.

Biochem. Pharmacol.

45

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1940

8526875

Characterization of human DNA ligase I expressed in a baculovirus-insect cell system

1995

Gallina, A.; Rossi, F.; Milanesi, G.; Rossi, R.; Montecucco, A.; Ciarrocchi, G.

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312

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1941

8615799

Natural-product inhibitors of human DNA ligase I

1996

Tan, G.T.; Lee, S.; Lee, I.S.; Chen, J.; Leitner, P.; Besterman, J.; Kinghorn, A.D.; Pezzuto, J.M.

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314

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1942

8698042

Inhibition of human DNA ligase I activity by zinc and cadmium and the fidelity of ligation

1996

Yang, S.W.; Becker, F.F.; Chan, J.Y.H.

Environ. Mol. Mutagen.

28

19-25

1943

8647114

Characterization of DNA ligase from the fungus Coprinus cinereus

1996

Matsuda, S.; Sakaguchi, K.; Tsukada, K.; Teraoka, H.

Eur. J. Biochem.

237

691-697

1944

9242410

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1997

Grawunder, U.; Wilm, M.; Wu, X.; Kuleza, P.; Wilson, T.E.; Mann, M.; Lieber, M.R.

Nature

388

492-495

1945

7721901

Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase

1995

Husain, I.; Tomkinson, A.E.; Burkhart, W.A.; Moyer, M.B.; Ramos, W.; Mackey, Z.B.; Besterman, J.M.; Chen, J.

J. Biol. Chem.

270

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1946

8626651

Bacteriophage T7 DNA ligase. Overexpression, purification, crystallization, and characterization

1996

Doherty, A.J.; Ashford, S.R.; Subramanya, H.S.; Wigley, D.B.

J. Biol. Chem.

271

11083-11089

1947

8798671

DNA ligase IV from HeLa cell nuclei

1996

Robin, P.; Lindahl, T.

J. Biol. Chem.

271

24257-24261

1948

2156493

Effects of DNA-binding drugs on T4 DNA ligase

1990

Montecuccho, A.; Pedrali-Noy, G.; Spadari, S.; Lestingi, M.; Ciarrocchi, G.

Biochem. J.

266

379-384

1949

1930131

Correlation between anthracycline structure and human DNA ligase inhibition

1991

Ciarrocchi, G.; Lestingi, M.; Fontana, M.; Spadari, S.; Montecuccho, A.

Biochem. J.

279

141-146

1950

8840507

A Candida albicans gene encoding a DNA ligase

1996

Andaluz, E.; Larriba, G.; Calderone, R.

Yeast

12

893-898

1951

7565692

Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination

1995

Chen, J.; Tomkinson, A.E.; Ramos, W.; Mackey, Z.B.; Danehower, S.; Walter, C.A.; Schultz, R.A.; Besterman, J.M.; Husain, I.

Mol. Cell. Biol.

15

5412-5422

1952

7989368

Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation

1994

Wang, Y.C.; Burkhart, W.A.; Mackey, Z.B.; Moyer, M.B.; Ramos, W.; Husain, I.; Chen, J.; Besterman, J.M.; Tomkinson, A.E.

J. Biol. Chem.

269

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1953

7760816

Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination

1995

Wei, Y.F.; Robins, P.; Carter, K.; Caldecott, K.; Pappin, D.J.; Yu, G.L.; Wang, R.P.; Shell, B.K.; Nash, R.A.; Schar, P.

Mol. Cell. Biol.

15

3206-3216

1954

8300757

Further purification and characterization of a multienzyme complex for DNA synthesis in human cells

1993

Li, C.; Cao, L.G.; Wang, Y.L.; Baril, E.F.

J. Cell. Biochem.

53

405-419

1955

8438592

African swine fever virus encodes a DNA ligase

1993

Yanez, R.J.; Vinuela, E.

Virology

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1956

1445910

DNA ligase I from Saccharomyces cerevisiae: physical and biochemical characterization of the CDC9 gene product

1992

Tomkinson, A.E.; Tappe, N.J.; Friedberg, E.C.

Biochemistry

31

11762-11771

1957

1939197

Three distinct DNA ligases in mammalian cells

1991

Tomkinson, A.E.; Roberts, E.; Daly, G.; Totty, N.F.; Lindahl, T.

J. Biol. Chem.

266

21728-21735

1958

2204063

Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae

1990

Barnes, D.E.; Johnston, L.H.; Kodama, K.; Tomkinson, A.E.; Lasko, D.D.; Lindahl, T.

Proc. Natl. Acad. Sci. USA

87

6679-6683

1959

1549587

Identification of a specific inhibitor for DNA ligase I in human cells

1992

Yang, S.W.; Becker, F.F.; Chan, J.Y.

Proc. Natl. Acad. Sci. USA

89

2227-2231

1960

1310314

Dual mode of inhibition of purified DNA ligase I from human cells by 9-beta-D-arabinofuranosyl-2-fluoroadenine triphosphate

1992

Yang, S.W.; Huang, P.; Plunkett, W.; Becker, F.F.; Chan, J.Y.

J. Biol. Chem.

267

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1961

1730240

Rat liver DNA ligase. Catalytic properties of a novel form of DNA ligase

1992

Elder, R.H.; Montecucco, A.; Carrocchi, G.; Rossignol, J.M.

Eur. J. Biochem.

203

53-58

1962

2383569

DNA ligases from rat liver. Purification and partial characterization of two molecular forms

1990

Elder, R.H.; Rossignol, J.M.

Biochemistry

29

6009-6017

1963

2017356

DNA ligase I from Xenopus leavis eggs

1991

Hardy, S.; Aoufouchi, S.; Thiebaud, P.; Prigent, C.

Nucleic Acids Res.

19

701-705

1964

2120058

Purification and characterization of DNA ligase II from Drosophila melanogaster

1990

Takahashi, M.; Tomizawa, K.

Eur. J. Biochem.

192

735-740

1965

3104089

Two distinct DNA ligases from Drosophila melanogaster embryos

1987

Takahashi, M.; Senshu, M.

FEBS Lett.

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1966

2340590

Purification of DNA ligases from mouse testis and their behavior during meiosis

1990

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1969

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Stimulation of intermolecular ligation with E. coli DNA ligase by high concentrations of monovalent cations in polyethylene glycol solutions

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Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli

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68

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1975

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Simultaneous preparation of a DNA ligase and restriction endonucleases from Bacillus amyloliquefaciens

1978

Shibata, T.; Hayase, E.; Ando, T.

Agric. Biol. Chem.

42

1613-1615

1976

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A simple, three-step procedure for the large scale purification of DNA ligase from a hybrid lysogen constructed in vitro

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Panasenko, S.M.; Alazard, R.J.; Lehman, I.R.

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1977

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Deoxyribonucleic acid ligase. Isolation and physical characterization of the homogenous enzyme from Escherichia coli

1973

Modrich, P.; Anraku, Y.; Lehman, I.R.

J. Biol. Chem.

248

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1978

9414650

Helicobacter pylori extracts exhibit nicotinamide adenine dinucleotide-derived adenylation but not mono(adenosine 5'-diphosphate-ribosyl)ation of DNA ligase

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1979

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Identification of essential residues in Thermus thermophilus DNA ligase

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3079-3085

1980

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Cloning sequence analysis of the DNA ligase-encoding gene of Rhodothermus marinus, and overproduction, purification and characterization of two thermophilic DNA ligase

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1981

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3802

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ATP-dependent exonuclease V from Micrococcus luteus. The enzyme-DNA complex, the processive mechanism, and the role of ATP

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Biochim. Biophys. Acta

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134022

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Studies on the mechanism of action of the ATP-dependent DNAase from Alcaligenes faecalis

1981

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Resolution and reconstitution of the rec BC deoxyribonuclease of Escherichia coli

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Biochemical characterization of a mutant recBCD enzyme, the recB2109CD enzyme, which lacks chi-specific, but not non-specific, nuclease activity

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Exonuclease VII of Escherichia coli

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Basic Life Sci.

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Exonuclease VII of E. coli

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Gene Amplif. Anal.

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Exonuclease VII of Escherichia coli. Purification and properties

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The assay and isolation of DNA rings using an ATP-dependent endonuclease

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Pyrimidine dimer excision in Escherichia coli strains deficient in exonucleases V and VII and in the 5' leads to 3' exonuclease of DNA polymerase I

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Use of an Escherichia coli mutant strain permits measurement of single-stranded apurinic-apyrimidinic endonuclease in crude extracts: studies with untransformed cells and cells transformed with plasmids containing the uvrC gene

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