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  • In Vivo Product
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• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
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Ligand acetoacetyl-CoA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

butanoate fermentation, citric acid cycle, CO2 fixation in Crenarchaeota, lipid metabolism, mevalonate metabolism, propanol degradation, tryptophan metabolism more

KEGG

Benzoate degradation, Biosynthesis of secondary metabolites, Butanoate metabolism, Carbon fixation pathways in prokaryotes, Carbon metabolism, Fatty acid degradation, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism, Lysine degradation, Microbial metabolism in diverse environments, Propanoate metabolism, Pyruvate metabolism, Synthesis and degradation of ketone bodies, Terpenoid backbone biosynthesis, Tryptophan metabolism, Valine, leucine and isoleucine degradation more

MetaCyc

(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), 2-deoxy-D-ribose degradation II, 2-methylpropene degradation, 3-hydroxypropanoate/4-hydroxybutanate cycle, acetoacetate degradation (to acetyl CoA), acetyl-CoA fermentation to butanoate II, crotonate fermentation (to acetate and cyclohexane carboxylate), ethylmalonyl-CoA pathway, ferrichrome A biosynthesis, glutaryl-CoA degradation, isoprene biosynthesis II (engineered), isopropanol biosynthesis (engineered), ketogenesis, ketolysis, L-glutamate degradation V (via hydroxyglutarate), L-lysine fermentation to acetate and butanoate, methyl tert-butyl ether degradation, mevalonate pathway I (eukaryotes and bacteria), mevalonate pathway II (haloarchaea), mevalonate pathway III (Thermoplasma), mevalonate pathway IV (archaea), oleate beta-oxidation, polyhydroxybutanoate biosynthesis, pyruvate fermentation to acetone, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), TCA cycle VI (Helicobacter) more

Show all BRENDA pathways known for acetoacetyl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (33 results)

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Show Natural Substrate (33 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.100

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

739901

-

1.1.1.100

acetoacetyl-CoA + NADPH = 3-hydroxybutyryl-CoA + NADP+

667646

-

1.1.1.100

2 entries

1.1.1.157

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutanoyl-CoA + NADP+

286047, 286053

4kuh, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-3-hydroxybutyryl-CoA + NAD+

286621

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-3-hydroxybutyryl-CoA + NAD+

286621

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-3-hydroxybutyryl-CoA + NAD+

286622, 286623, 286614

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-3-hydroxybutyryl-CoA + NAD+

286622, 286623, 286614

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutyryl-CoA + NADP+

701808

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutyryl-CoA + NADP+

701808

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

740743

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

740743

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = (R)-3-hydroxybutyryl-CoA + NADP+

657106

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = (R)-3-hydroxybutyryl-CoA + NADP+

657106

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = ?

286620

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = ?

286620

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-3-hydroxybutyryl-CoA + NADP+

286621, 286614, 286623, 286622

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-3-hydroxybutyryl-CoA + NADP+

286621, 286614, 286623, 286622

4n5m, 3D-view

1.1.1.36

14 entries

2.3.1.16

CoA + acetoacetyl-CoA = 2 acetyl-CoA

735368

5lnq, 3D-view

2.3.1.9

acetoacetyl-CoA + CoA = 2 acetyl-CoA

706822

1m1o, 3D-view

2.3.1.9

CoA + acetoacetyl-CoA = 2 acetyl-CoA

735404, 735609, 736252, 727751, 726748, 748648

1m1o, 3D-view

2.3.1.9

CoA + acetoacetyl-CoA = acetyl-CoA + acetyl-CoA

487669, 487671, 486410, 487690, 487673, 487678, 487688, 487697, 486408, 487667, 487670, 487674, 487666, 487675, 487677, 487687, 487668, 487681, 487682, 487683, 487692, 487698, 487702, 288676, 487694, 486430, 286047, 487672, 487695, 487691, 487684, 487693, 486875, 487703, 487701, 487699, 487676, 486436, 487680

1m1o, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488098, 488103, 488105, 488106, 488110, 488111, 488113, 488114, 488115, 488116, 488118, 488107, 488122, 488093, 488109, 488112, 488094, 488099, 488102, 488108, 488120, 488096, 488097, 488101, 488095, 488104, 488117, 488119, 488123, 488092, 488091, 488121, 488100, 657850, 659403, 660160

1xpk, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488098, 488103, 488105, 488106, 488110, 488111, 488113, 488114, 488115, 488116, 488118, 488107, 488122, 488093, 488109, 488112, 488094, 488099, 488102, 488108, 488120, 488096, 488097, 488101, 488095, 488104, 488117, 488119, 488123, 488092, 488091, 488121, 488100, 657850, 659403, 660160

1xpl, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488098, 488103, 488105, 488106, 488110, 488111, 488113, 488114, 488115, 488116, 488118, 488107, 488122, 488093, 488109, 488112, 488094, 488099, 488102, 488108, 488120, 488096, 488097, 488101, 488095, 488104, 488117, 488119, 488123, 488092, 488091, 488121, 488100, 657850, 659403, 660160

1xpm, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488098, 488103, 488105, 488106, 488110, 488111, 488113, 488114, 488115, 488116, 488118, 488107, 488122, 488093, 488109, 488112, 488094, 488099, 488102, 488108, 488120, 488096, 488097, 488101, 488095, 488104, 488117, 488119, 488123, 488092, 488091, 488121, 488100, 657850, 659403, 660160

5hwq, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 736978, 756421, 706833, 706004, 726092, 737147, 737238, 736848, 736321, 736677, 757711, 727772, 756880, 758236, 758969

1xpk, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 736978, 756421, 706833, 706004, 726092, 737147, 737238, 736848, 736321, 736677, 757711, 727772, 756880, 758236, 758969

1xpl, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 736978, 756421, 706833, 706004, 726092, 737147, 737238, 736848, 736321, 736677, 757711, 727772, 756880, 758236, 758969

1xpm, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 736978, 756421, 706833, 706004, 726092, 737147, 737238, 736848, 736321, 736677, 757711, 727772, 756880, 758236, 758969

5hwq, 3D-view

2.3.1.9

3 entries

2.3.3.10

8 entries

2.8.3.8

acetoacetyl-CoA + acetate = acetoacetate + acetyl-CoA

737906

-

2.8.3.9

butanoate + acetoacetyl-CoA = butanoyl-CoA + acetoacetate

643837, 643839, 643838

-

3.1.2.11

acetoacetyl-CoA + H2O = ?

80976, 80977, 80972

-

6.3.2.50

ATP + L-isoleucine + acetoacetyl-CoA = AMP + diphosphate + tenuazonic acid + CoA

741052

-

In Vivo Product in Enzyme-catalyzed Reactions (39 results)

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Show Natural Product (39 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.34

acetyl-CoA = acetoacetyl-CoA + CoA

-

-

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286602, 286052, 286591, 286592,

5mgb, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1f0y, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1il0, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1m75, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1m76, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

4pze, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

5mgb, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NADPH + H+ = 3-oxobutyryl-CoA + NADP+

-

3vzs, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NADPH + H+ = 3-oxobutyryl-CoA + NADP+

-

4n5m, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

3vzs, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

4n5m, 3D-view

1.1.1.35

24 entries

1.1.1.36

4 entries

2.3.1.16

2 acetyl-CoA = CoA + acetoacetyl-CoA

-

5lnq, 3D-view

2.3.1.194

acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2

-

-

2.3.1.194

acetyl-CoA + malonyl-CoA = CoA + acetoacetyl-CoA + CO2

-

-

2.3.1.9

2 acetyl-CoA = acetoacetyl-CoA + CoA

-

1m1o, 3D-view

2.3.1.9

2 acetyl-CoA = CoA + acetoacetyl-CoA

-

1m1o, 3D-view

2.3.1.9

acetyl-CoA + acetyl-CoA = CoA + acetoacetyl-CoA

-

1m1o, 3D-view

2.6.1.111

(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate

-

-

2.6.1.111

(3S)-3-aminobutanoyl-CoA + pyruvate = acetoacetyl-CoA + L-alanine

-

-

2.3.1.194

2 entries

2.3.1.9

3 entries

2.6.1.111

2 entries

2.8.3.5

succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA

-

-

6.2.1.16

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

-

-

Substrate in Enzyme-catalyzed Reactions (153 results)

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Show Substrate (153 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.100

acetoacetyl-CoA + NADH + H+ = ?

741044

-

1.1.1.100

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

739774, 739901

-

1.1.1.100

acetoacetyl-CoA + NADPH + H+ = ?

740630, 740558, 740023, 741044

-

1.1.1.100

acetoacetyl-CoA + NADPH = 3-hydroxybutyryl-CoA + NADP+

667257, 669013, 667646, 667708, 670774, 706639, 668574, 667520, 689435

-

1.1.1.100

acetoacetyl-CoA + NADPH = ? + NADP+

703630

-

1.1.1.100

acetoacetyl-CoA + NADPH = D-3-hydroxybutyryl-CoA + NADP+

724676

-

1.1.1.100

acetoacetyl-CoA + NADPH = D-beta-hydroxybutyryl-CoA + NADP+

655871, 285668, 285683, 285672, 285670, 285673, 285674, 285679, 654432, 703163

-

1.1.1.100

7 entries

1.1.1.149

acetoacetyl-CoA + NADPH = NADP+ + ?

285999

-

1.1.1.157

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutanoyl-CoA + NADP+

286046, 286047, 286053

4kuh, 3D-view

1.1.1.211

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

286269

-

1.1.1.212

acetoacetyl-CoA + NADH = 3-hydroxybutanoyl-CoA + NAD+

285678

-

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1f0y, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1il0, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1m75, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1m76, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

4pze, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

5mgb, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1f0y, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1il0, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1m75, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

1m76, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

4pze, 3D-view

1.1.1.35

3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutyryl-CoA + NAD+

712966

5mgb, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

1f0y, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

1il0, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

1m75, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

1m76, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

4pze, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH + H+ = 3-hydroxybutyryl-CoA + NAD+

699171

5mgb, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

1f0y, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

1il0, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

1m75, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

1m76, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

4pze, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = (S)-3-hydroxybutyryl-CoA + NAD+

657049

5mgb, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

1f0y, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

1il0, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

1m75, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

1m76, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

4pze, 3D-view

1.1.1.35

acetoacetyl-CoA + NADH = 3-hydroxybutyryl-CoA + NAD+

657276, 695470

5mgb, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-3-hydroxybutyryl-CoA + NAD+

286621

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-3-hydroxybutyryl-CoA + NAD+

286621

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-beta-hydroxybutyryl-CoA + NAD+

286617, 286618

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = D-beta-hydroxybutyryl-CoA + NAD+

286617, 286618

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-3-hydroxybutyryl-CoA + NAD+

286622, 286623, 668057, 669878, 667282, 667285, 286614

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-3-hydroxybutyryl-CoA + NAD+

286622, 286623, 668057, 669878, 667282, 667285, 286614

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-beta-hydroxybutyryl-CoA + NAD+

286623

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADH = L-beta-hydroxybutyryl-CoA + NAD+

286623

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (3R)-3-hydroxybutyryl-CoA + NADP+

286615, 286617, 286621, 286614, 286619, 286620, 286613, 286616

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (3R)-3-hydroxybutyryl-CoA + NADP+

286615, 286617, 286621, 286614, 286619, 286620, 286613, 286616

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutanoyl-CoA +NADP+

286622

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutanoyl-CoA +NADP+

286622

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutyryl-CoA + NADP+

701808

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = (R)-3-hydroxybutyryl-CoA + NADP+

701808

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

740743

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH + H+ = 3-hydroxybutyryl-CoA + NADP+

740743

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = (R)-3-hydroxybutyryl-CoA + NADP+

657106, 656318

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = (R)-3-hydroxybutyryl-CoA + NADP+

657106, 656318

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = ?

286620

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = ?

286620

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-3-hydroxybutyryl-CoA + NADP+

286621, 286614, 286623, 286622

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-3-hydroxybutyryl-CoA + NADP+

286621, 286614, 286623, 286622

4n5m, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-beta-hydroxybutyryl-CoA + NADP+

286613, 286625, 286622, 286623

3vzs, 3D-view

1.1.1.36

acetoacetyl-CoA + NADPH = D-beta-hydroxybutyryl-CoA + NADP+

286613, 286625, 286622, 286623

4n5m, 3D-view

1.1.1.35

30 entries

1.1.1.36

24 entries

2.1.3.1

acetoacetyl-CoA + oxaloacetate = 3-oxoglutaryl-CoA + pyruvate

485817, 485816

-

2.3.1.137

acetoacetyl-CoA + L-carnitine = acetoacetyl-L-carnitine + CoA

486292

-

2.3.1.155

acetoacetyl-CoA + CoA = acetyl-CoA + acetyl-CoA

288681, 288678, 288682, 288679

-

2.3.1.157

acetoacetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetoacetyl-alpha-D-glucosamine 1-phosphate

756049

-

2.3.1.16

acetoacetyl-CoA + CoA = 2 acetyl-CoA

757515

5lnq, 3D-view

2.3.1.16

CoA + acetoacetyl-CoA = 2 acetyl-CoA

735368

5lnq, 3D-view

2.3.1.16

CoA + acetoacetyl-CoA = acetyl-CoA + acetyl-CoA

2962, 486435, 660434, 486403, 486412, 486404, 288676, 486427, 486430

5lnq, 3D-view

2.3.1.16

coenzyme A + acetoacetyl-CoA = 2 acetyl-CoA

675941

5lnq, 3D-view

2.3.1.165

acetoacetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methyl triacetic acid lactone + CoA + NADP+

735433

-

2.3.1.165

acetoacetyl-CoA + malonyl-CoA + NADPH = ?

486447

-

2.3.1.165

acetoacetyl-CoA + malonyl-CoA = 6-methyl triacetic acid lactone + CoA

486451

-

2.3.1.16

4 entries

2.3.1.165

3 entries

2.3.1.19

acetoacetyl-CoA + phosphate = acetoacetylphosphate + CoA

486469

-

2.3.1.233

acetoacetyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-methyl-2-pyrone + CoA + CO2 + H2O

729966

-

2.3.1.233

acetoacetyl-CoA + methylmalonyl-CoA = 3,6-dimethyl-4-hydroxy-2-pyrone + CoA + CO2 + H2O

729961

-

2.3.1.233

acetoacetyl-CoA = 4-hydroxy-6-methyl-2-pyrone + CoA + CO2 + H2O

729966, 729961

-

2.3.1.253

acetoacetyl-CoA = monoacetylphloroglucinol + ?

740598

-

2.3.1.253

acetoacetyl-CoA = phloroglucinol + 4-hydroxy-6-methyl-2H-pyran-2-one + CO2 + CoA

740681

-

2.3.1.39

acetoacetyl-CoA + acyl-carrier protein = CoA + acetoacetyl-[acyl-carrier protein]

4866

-

2.3.1.39

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + acetoacetyl-[acyl carrier protein]

755871

-

2.3.1.39

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + an acetoacetyl-[acyl-carrier protein]

755871

-

2.3.1.233

3 entries

2.3.1.253

2 entries

2.3.1.39

3 entries

2.3.1.60

acetoacetyl-CoA + gentamicin = CoA + N3'-acetoacetyl-gentamicin

706886

-

2.3.1.7

acetoacetyl-CoA + L-(-)carnitine = O-acetoacetyl(-)carnitine + CoASH

487404

-

2.3.1.85

acetoacetyl-CoA + an [acyl-carrier protein] = CoA + acetoacetyl-[acyl-carrier protein]

755686

-

2.3.1.85

acetoacetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+

758301

-

2.3.1.9

acetoacetyl-CoA + CoA = 2 acetyl-CoA

706822, 719606, 704063, 702812

1m1o, 3D-view

2.3.1.9

CoA + acetoacetyl-CoA = 2 acetyl-CoA

748648, 726748, 727751, 735404, 735609, 736252, 737008, 755715, 755863

1m1o, 3D-view

2.3.1.9

CoA + acetoacetyl-CoA = acetyl-CoA + acetyl-CoA

487669, 487671, 486410, 487690, 676035, 487673, 487678, 487688, 487697, 487676, 487699, 486408, 487667, 487670, 487674, 487666, 487675, 487677, 487687, 487668, 487681, 487682, 487683, 487692, 487698, 487702, 288676, 487694, 486430, 286047, 487672, 487695, 487691, 487684, 487693, 486875, 487703, 486436, 487701, 487680

1m1o, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpk, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpl, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpm, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

5hwq, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpk, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpl, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

1xpm, 3D-view

2.3.3.10

3-oxobutyryl-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA

488107, 488115

5hwq, 3D-view

2.3.3.10

acetyl-3'-dephospho-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + 3'-dephospho-CoA

488107, 488097

1xpk, 3D-view

2.3.3.10

acetyl-3'-dephospho-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + 3'-dephospho-CoA

488107, 488097

1xpl, 3D-view

2.3.3.10

acetyl-3'-dephospho-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + 3'-dephospho-CoA

488107, 488097

1xpm, 3D-view

2.3.3.10

acetyl-3'-dephospho-CoA + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + 3'-dephospho-CoA

488107, 488097

5hwq, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488093, 488096, 488098, 488099, 488100, 488101, 488102, 488103, 488105, 488106, 488110, 488111, 488112, 488113, 488114, 488115, 488116, 488118, 488119, 488123, 488095, 488107, 488117, 488122, 659403, 488109, 720426, 488094, 488108, 488120, 488092, 488097, 488091, 488104, 660322, 657850, 660160, 720647, 488121, 720239, 718933

1xpk, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488093, 488096, 488098, 488099, 488100, 488101, 488102, 488103, 488105, 488106, 488110, 488111, 488112, 488113, 488114, 488115, 488116, 488118, 488119, 488123, 488095, 488107, 488117, 488122, 659403, 488109, 720426, 488094, 488108, 488120, 488092, 488097, 488091, 488104, 660322, 657850, 660160, 720647, 488121, 720239, 718933

1xpl, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488093, 488096, 488098, 488099, 488100, 488101, 488102, 488103, 488105, 488106, 488110, 488111, 488112, 488113, 488114, 488115, 488116, 488118, 488119, 488123, 488095, 488107, 488117, 488122, 659403, 488109, 720426, 488094, 488108, 488120, 488092, 488097, 488091, 488104, 660322, 657850, 660160, 720647, 488121, 720239, 718933

1xpm, 3D-view

2.3.3.10

acetyl-CoA + acetoacetyl-CoA + H2O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

488093, 488096, 488098, 488099, 488100, 488101, 488102, 488103, 488105, 488106, 488110, 488111, 488112, 488113, 488114, 488115, 488116, 488118, 488119, 488123, 488095, 488107, 488117, 488122, 659403, 488109, 720426, 488094, 488108, 488120, 488092, 488097, 488091, 488104, 660322, 657850, 660160, 720647, 488121, 720239, 718933

5hwq, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 745472, 736978, 756421, 706833, 706004, 726092, 727772, 737147, 737238, 736848, 736321, 736677, 757711, 756880, 758236, 758969

1xpk, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 745472, 736978, 756421, 706833, 706004, 726092, 727772, 737147, 737238, 736848, 736321, 736677, 757711, 756880, 758236, 758969

1xpl, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 745472, 736978, 756421, 706833, 706004, 726092, 727772, 737147, 737238, 736848, 736321, 736677, 757711, 756880, 758236, 758969

1xpm, 3D-view

2.3.3.10

acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

701677, 745472, 736978, 756421, 706833, 706004, 726092, 727772, 737147, 737238, 736848, 736321, 736677, 757711, 756880, 758236, 758969

5hwq, 3D-view

2.3.3.10

acetylglutathione + acetoacetyl-CoA + H2O = ?

488097

1xpk, 3D-view

2.3.3.10

acetylglutathione + acetoacetyl-CoA + H2O = ?

488097

1xpl, 3D-view

2.3.3.10

acetylglutathione + acetoacetyl-CoA + H2O = ?

488097

1xpm, 3D-view

2.3.3.10

acetylglutathione + acetoacetyl-CoA + H2O = ?

488097

5hwq, 3D-view

2.3.3.10

acetylpantetheine + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + pantetheine

488097

1xpk, 3D-view

2.3.3.10

acetylpantetheine + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + pantetheine

488097

1xpl, 3D-view

2.3.3.10

acetylpantetheine + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + pantetheine

488097

1xpm, 3D-view

2.3.3.10

acetylpantetheine + acetoacetyl-CoA + H2O = 3-hydroxy-3-methylglutaryl-CoA + pantetheine

488097

5hwq, 3D-view

2.3.1.85

2 entries

2.3.1.9

3 entries

2.3.3.10

28 entries

2.7.8.7

acetoacetyl-CoA + apo-[acyl-carrier protein] = ? + holo-[acyl-carrier protein]

674285, 645408

-

2.8.3.8

acetoacetyl-CoA + acetate = acetoacetate + acetyl-CoA

737906

-

2.8.3.9

3-hydroxypropanoate + acetoacetyl-CoA = 3-hydroxypropanoyl-CoA + acetoacetate

643838

-

2.8.3.9

3-mercaptopropionate + acetoacetyl-CoA = 3-mercaptopropionyl-CoA + acetoacetate

643838

-

2.8.3.9

3-methylvinylacetate + acetoacetyl-CoA = 3-methylvinylacetyl-CoA + acetoacetate

643838

-

2.8.3.9

4-hydroxybutyrate + acetoacetyl-CoA = 4-hydroxybutanoyl-CoA + acetoacetate

643838

-

2.8.3.9

4-pentenoate + acetoacetyl-CoA = 4-pentenoyl-CoA + acetoacetate

643837

-

2.8.3.9

acetate + acetoacetyl-CoA = acetyl-CoA + acetoacetate

643839, 643838, 737542, 643837

-

2.8.3.9

acrylate + acetoacetyl-CoA = acrylyl-CoA + acetoacetate

643838

-

2.8.3.9

butanoate + acetoacetyl-CoA = butanoyl-CoA + acetoacetate

643837, 643839, 643838, 737542

-

2.8.3.9

crotonate + acetoacetyl-CoA = crotonyl-CoA + acetoacetate

643838

-

2.8.3.9

DL-2-hydroxybutyrate + acetoacetyl-CoA = 2-hydroxybutyryl-CoA + acetoacetate

643838

-

2.8.3.9

DL-2-hydroxypentanoate + acetoacetyl-CoA = 2-hydroxypentanoyl-CoA + acetoacetate

643838

-

2.8.3.9

DL-3-hydroxybutyrate + acetoacetyl-CoA = 3-hydroxybutyryl-CoA + acetoacetate

643838

-

2.8.3.9

formate + acetoacetyl-CoA = formyl-CoA + acetoacetate

643837

-

2.8.3.9

isobutyrate + acetoacetyl-CoA = isobutyryl-CoA + acetoacetate

643838

-

2.8.3.9

isopentanoate + acetoacetyl-CoA = isopentanoyl-CoA + acetoacetate

643838

-

2.8.3.9

monochloroacetate + acetoacetyl-CoA = monochloroacetyl-CoA + acetoacetate

643838

-

2.8.3.9

octanoate + acetoacetyl-CoA = octanoyl-CoA + acetoacetate

643837

-

2.8.3.9

pentanoate + acetoacetyl-CoA = pentanoyl-CoA + acetoacetate

643838

-

2.8.3.9

propionate + acetoacetyl-CoA = propionyl-CoA + acetoacetate

643839, 643838

-

2.8.3.9

vinylacetate + acetoacetyl-CoA = vinylacetyl-CoA + acetoacetate

643838

-

3.1.2.1

acetoacetyl-CoA + H2O = CoA + acetoacetate

732297

-

3.1.2.1

acetoacetyl-CoA = acetoacetate + CoA

94468, 94472, 94476, 94470

-

3.1.2.11

acetoacetyl-CoA + H2O = ?

80976, 80977, 80972

-

3.1.2.11

acetoacetyl-CoA + H2O = acetoacetate + CoA

80975, 80977, 5360, 80971, 80973, 80976, 80980, 80972, 80978, 80979

-

2.8.3.9

20 entries

3.1.2.1

2 entries

3.1.2.11

2 entries

3.1.2.18

acetoacetyl-CoA + H2O = acetoacetate + CoA

646114

-

3.1.2.2

acetoacetyl-CoA + H2O = CoA + acetoacetate

646200, 646180, 646165

-

3.1.2.20

acetoacetyl-CoA + H2O = CoA + acetoacetate

646200, 690932, 646180, 646165

-

3.1.2.32

acetoacetyl-CoA + H2O = 3-oxobutanoic acid + CoA

738043

-

3.5.1.51

acetoacetyl-CoA + H2O = ?

209188

-

6.3.2.50

ATP + L-isoleucine + acetoacetyl-CoA = AMP + diphosphate + tenuazonic acid + CoA

741052

-

6.4.1.4

ATP + acetoacetyl-CoA + HCO3- = ?

1896, 1884

-

Product in Enzyme-catalyzed Reactions (83 results)

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Show Product (83 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.178

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

-

1.1.1.34

acetyl-CoA = acetoacetyl-CoA + CoA

-

-

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-acetoacetyl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutanoyl-CoA + NADP+ = acetoacetyl-CoA + NADPH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

2207, 2962, 286588, 286589, 286269, 286601, 286603, 286604, 33713, 286590, 286593, 286594, 286596, 286598, 286606, 286607, 286608, 286609, 286610, 286611, 286612, 286602, 286052, 286591, 286592,

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH + H+

-

5mgb, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

1f0y, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

1il0, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

1m75, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

1m76, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

4pze, 3D-view

1.1.1.35

(S)-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286602, 286601

5mgb, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1f0y, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1il0, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1m75, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

1m76, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

4pze, 3D-view

1.1.1.35

3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

5mgb, 3D-view

1.1.1.36

(3R)-hydroxybutyryl-CoA + NADP+ = 3-oxobutyryl-CoA + NADPH + H+

-

3vzs, 3D-view

1.1.1.36

(3R)-hydroxybutyryl-CoA + NADP+ = 3-oxobutyryl-CoA + NADPH + H+

-

4n5m, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

3vzs, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = 3-oxobutyryl-CoA + NADH + H+

-

4n5m, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NADPH + H+ = 3-oxobutyryl-CoA + NADP+

-

3vzs, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NADPH + H+ = 3-oxobutyryl-CoA + NADP+

-

4n5m, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

3vzs, 3D-view

1.1.1.36

(R)-3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH

-

4n5m, 3D-view

1.1.1.36

D-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286619

3vzs, 3D-view

1.1.1.36

D-3-hydroxybutyryl-CoA + NADP+ = acetoacetyl-CoA + NADPH

286619

4n5m, 3D-view

1.1.1.35

48 entries

1.1.1.36

10 entries

1.3.8.1

3-hydroxybutyryl-CoA + acceptor = acetoacetyl-CoA + reduced acceptor

391284, 391292

-

2.3.1.137

acetoacetyl-L-carnitine + CoA = acetoacetyl-CoA + L-carnitine

-

-

2.3.1.16

2 acetyl-CoA = CoA + acetoacetyl-CoA

-

5lnq, 3D-view

2.3.1.180

acetoacetyl-ACP + acetyl-CoA = acetyl-ACP + acetoacetyl-CoA

-

-

2.3.1.194

2 malonyl-CoA = acetoacetyl-CoA + CoA + 2 CO2

-

-

2.3.1.194

acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2

-

-

2.3.1.194

acetyl-CoA + malonyl-CoA = CoA + acetoacetyl-CoA + CO2

-

-

2.3.1.194

3 entries

2.3.1.41

acetyl-CoA + malonyl-CoA = 3-oxobutyryl-CoA + CoA

-

-

2.3.1.7

O-acetoacetyl(-)carnitine + CoASH = acetoacetyl-CoA + L-(-)carnitine

-

-

2.3.1.9

2 acetyl-CoA = acetoacetyl-CoA + CoA

-

1m1o, 3D-view

2.3.1.9

2 acetyl-CoA = CoA + acetoacetyl-CoA

-

1m1o, 3D-view

2.3.1.9

acetyl-CoA + acetyl-CoA = CoA + acetoacetyl-CoA

-

1m1o, 3D-view

2.6.1.111

(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate

-

-

2.6.1.111

(3S)-3-aminobutanoyl-CoA + pyruvate = acetoacetyl-CoA + L-alanine

-

-

2.3.1.9

3 entries

2.6.1.111

2 entries

2.8.3.1

acetyl-CoA + acetoacetate = acetate + acetoacetyl-CoA

-

-

2.8.3.18

acetoacetate + succinyl-CoA = succinate + acetoacetyl-CoA

-

-

2.8.3.18

acetyl-CoA + acetoacetate = acetoacetyl-CoA + acetate

-

-

2.8.3.18

succinyl-CoA + acetoacetate = acetoacetyl-CoA + succinate

-

-

2.8.3.18

3 entries

2.8.3.5

succinyl-CoA + acetoacetate = succinate + acetoacetyl-CoA

80975, , 645977, 645975, 645976, 645972, 645978, 645971, 645988, 645967, 645969, 645970, 645979, 645986, 645980, 645968

-

2.8.3.9

acetyl-CoA + acetoacetate = acetate + acetoacetyl-CoA

643837

-

2.8.3.9

butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA

643838

-

2.8.3.9

epsilon-acetyl-CoA + acetoacetate = acetate + acetoacetyl-CoA

643837

-

2.8.3.9

3 entries

6.2.1.16

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

653080, , 649794, 650484, 649800, 653079, 649, 647

-

Activator in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Activating Compound (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.11.2

slight activation

642139

-

4.1.1.31

activates

4337

-

6.4.1.1

activation in decreasing order: acetyl-CoA, n-propanyl-CoA, n-butanoyl-CoA, malonyl-CoA/ CoA, acetoacetyl-CoA, oleoyl-CoA

1760

-

Inhibitor in Enzyme-catalyzed Reactions (75 results)

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Show Inhibitors (75 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.30

1 mM, 29% inhibition

286534

-

1.1.1.34

-

286559

-

1.1.1.36

-

286622, 286623

3vzs, 3D-view

1.1.1.36

-

286622, 286623

4n5m, 3D-view

1.1.1.36

above 0.01 mM

286614, 286620

3vzs, 3D-view

1.1.1.36

above 0.01 mM

286614, 286620

4n5m, 3D-view

1.1.1.36

concentration above 40 mM

286622

3vzs, 3D-view

1.1.1.36

concentration above 40 mM

286622

4n5m, 3D-view

1.1.1.36

markedly at concentrations above 0.005 mM and NADPH 0.01 mM, less inhibition when NADPH increases from 0.01 to 1 mM

286619

3vzs, 3D-view

1.1.1.36

markedly at concentrations above 0.005 mM and NADPH 0.01 mM, less inhibition when NADPH increases from 0.01 to 1 mM

286619

4n5m, 3D-view

1.1.1.36

NADH-linked, less sensitive; NADPH-linked, concentration above 0.025 mM, nearly independent of NADPH concentrations 0.03-0.5 mM

286623

3vzs, 3D-view

1.1.1.36

NADH-linked, less sensitive; NADPH-linked, concentration above 0.025 mM, nearly independent of NADPH concentrations 0.03-0.5 mM

286623

4n5m, 3D-view

1.3.1.9

-

675299

-

1.3.1.9

about 20% inhibition at 0.2 mM

739906

-

1.3.8.1

-

391266, 391283, 656039

-

1.3.8.1

0.5 mM, 60% inhibition, apo-enzyme reconstituted with FAD

391260

-

1.1.1.36

10 entries

1.3.1.9

2 entries

1.3.8.1

2 entries

1.3.8.5

-

12302

-

1.3.8.6

-

391406, 391409

-

1.3.8.7

-

391358

-

2.3.1.16

competitive inhibition of the acetyl-CoA hydrolase activity

664215

5lnq, 3D-view

2.3.1.16

substrate inhibition at high concentrations

675941

5lnq, 3D-view

2.3.1.16

2 entries

2.3.1.39

inhibition of both isozymes at 0.02 mM and at 0.1 mM

486887

-

2.3.1.5

0.1 mM, 44% inhibtion

657884

-

2.3.1.9

thiolysis reaction shows a substrate inhibition at high concentrations; when one of the substrates (acetoacetyl CoA or CoA) is varied, while the concentrations of the second substrates (CoA or acetoacetyl CoA respectively) remain constant

748648

1m1o, 3D-view

2.3.1.9

-

487675

1m1o, 3D-view

2.3.1.9

isoenzyme A: above 0.015 mM, isoenzyme B: above 0.01 mM

487678

1m1o, 3D-view

2.3.1.9

substrate inhibition above 0.105 mM

487690

1m1o, 3D-view

2.3.1.9

substrate inhibition beyond 0.0225 mM

676035

1m1o, 3D-view

2.3.3.10

-

488095, 488096, 488097, 488098, 488099, 488100, 488101, 488103, 488107, 488111, 488116

1xpk, 3D-view

2.3.3.10

-

488095, 488096, 488097, 488098, 488099, 488100, 488101, 488103, 488107, 488111, 488116

1xpl, 3D-view

2.3.3.10

-

488095, 488096, 488097, 488098, 488099, 488100, 488101, 488103, 488107, 488111, 488116

1xpm, 3D-view

2.3.3.10

-

488095, 488096, 488097, 488098, 488099, 488100, 488101, 488103, 488107, 488111, 488116

5hwq, 3D-view

2.3.3.10

competitive inhibition

488103

1xpk, 3D-view

2.3.3.10

competitive inhibition

488103

1xpl, 3D-view

2.3.3.10

competitive inhibition

488103

1xpm, 3D-view

2.3.3.10

competitive inhibition

488103

5hwq, 3D-view

2.3.3.10

inhibition of wild-type enzyme, no inhibition of mutant enzyme H188N and H188N/S259A

657850

1xpk, 3D-view

2.3.3.10

inhibition of wild-type enzyme, no inhibition of mutant enzyme H188N and H188N/S259A

657850

1xpl, 3D-view

2.3.3.10

inhibition of wild-type enzyme, no inhibition of mutant enzyme H188N and H188N/S259A

657850

1xpm, 3D-view

2.3.3.10

inhibition of wild-type enzyme, no inhibition of mutant enzyme H188N and H188N/S259A

657850

5hwq, 3D-view

2.3.3.10

potent inhibitor of the overall reaction

671988

1xpk, 3D-view

2.3.3.10

potent inhibitor of the overall reaction

671988

1xpl, 3D-view

2.3.3.10

potent inhibitor of the overall reaction

671988

1xpm, 3D-view

2.3.3.10

potent inhibitor of the overall reaction

671988

5hwq, 3D-view

2.3.3.10

substrate inhibition

488091, 488102, 720647

1xpk, 3D-view

2.3.3.10

substrate inhibition

488091, 488102, 720647

1xpl, 3D-view

2.3.3.10

substrate inhibition

488091, 488102, 720647

1xpm, 3D-view

2.3.3.10

substrate inhibition

488091, 488102, 720647

5hwq, 3D-view

2.3.1.9

5 entries

2.3.3.10

20 entries

2.7.1.33

-

641393

-

2.7.11.4

-

349056, 640583

-

2.7.11.4

40% inhibition at 0.01 mM

640579

-

2.7.11.4

2 entries

2.8.3.13

non-competitive inhibition

643833

-

2.8.3.5

EDTA, trisodium citrate and diphosphate protect, too, addition of Cu2+, Mn2+, Ca2+ or Zn2+ (decreasing order) restores inactivating activity of acetoacetyl-CoA; in the absence of succinate, cysteine restores, succinate or 0.1 M NaCl protects

645967

-

2.8.3.5

product inhibition, kinetics

645980

-

3.1.2.4

competitive

94558

-

3.1.2.4

competitive inhibition

653127

-

2.8.3.5

2 entries

3.1.2.4

2 entries

4.2.1.149

0.1 mM, 25% inhibition

724139

-

4.2.1.17

-

5866, 697604

1dub, 3D-view

4.2.1.17

-

5866, 697604

3q0j, 3D-view

4.2.1.17

-

5866, 697604

4fn8, 3D-view

4.2.1.17

-

5866, 697604

4omr, 3D-view

4.2.1.17

-

5866, 697604

5mgb, 3D-view

4.2.1.17

competitive inhibitor, binding structure, overview

730574

1dub, 3D-view

4.2.1.17

competitive inhibitor, binding structure, overview

730574

3q0j, 3D-view

4.2.1.17

competitive inhibitor, binding structure, overview

730574

4fn8, 3D-view

4.2.1.17

competitive inhibitor, binding structure, overview

730574

4omr, 3D-view

4.2.1.17

competitive inhibitor, binding structure, overview

730574

5mgb, 3D-view

4.2.1.17

enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme

33730

1dub, 3D-view

4.2.1.17

enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme

33730

3q0j, 3D-view

4.2.1.17

enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme

33730

4fn8, 3D-view

4.2.1.17

enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme

33730

4omr, 3D-view

4.2.1.17

enolate form of acetoacetyl-CoA acts as a competitive inhibitor. 6 molecules of inhibitor are bound per molecule of enzyme

33730

5mgb, 3D-view

4.2.1.17

15 entries

5.1.99.4

-

681420

2gd2, 3D-view

6.4.1.4

-

1896, 653128

-

6.4.1.4

95% inhibition

653013

-

6.4.1.4

2 entries