Ligand 2-aminoisobutanoate

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Basic Ligand Information

Molecular Structure
Picture of 2-aminoisobutanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2
2-aminoisobutanoate
FUOOLUPWFVMBKG-UHFFFAOYSA-N
Synonyms:
2-aminoisobutyrate, 2-aminoisobutyric acid, alpha-aminoisobutryric acid, alpha-aminoisobutyrate, alpha-aminoisobutyric acid
Pathway Source
Pathways

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
alpha-aminoisobutyric acid + L-ascorbate + O2 = ammonia + acetone + dehydroascorbate + CO2 + H2O
-
show the reaction diagram
pyruvate + 2-aminoisobutanoate = L-alanine + 2-oxo-3-methylpropanoate
-
show the reaction diagram
ATP + H2O + alpha-aminoisobutyric acid/out = ADP + phosphate + alpha-aminoisobutyric acid/in
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
alpha-aminoisobutyric acid methyl ester + H2O = alpha-aminoisobutyric acid + methanol
-
-
show the reaction diagram
ATP + H2O + alpha-aminoisobutyric acid/out = ADP + phosphate + alpha-aminoisobutyric acid/in
-

Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
activates enzyme ACCO, prevents enzyme inactivation
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
22.5% inhibition at 10 mM
-
competitive inhibitor; competitive inhibitor
competitive to 1-aminocyclopropane-1-carboxylate
-
allosteric inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
recombinant enzyme, pH 7.0, 30°C
0.07
-
activated by Ba2+
1.4
-
activated by Ca2+
0.05
-
activated by Cs+
3.8
-
activated by K+
10.4
-
activated by Li+
0.86
-
activated by Mg2+
0.076
-
activated by Na+
1.83
-
activated by NH4+
4.9
-
activated by Rb+
7.4
-
activated by Tl+
5.22
-
enzyme with K+ in the metal binding site
13.1
-
enzyme with Na+ in the metal binding site
1.29
-
enzyme with Rb+ in the metal binding site
4.47
-
pH 7.8, mutant enzyme Q52A
0.12
-
with pyruvate as cosubstrate, decarboxylation
25
-

KM Value (18 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
recombinant enzyme, pH 7.0, 30°C
14.7
-
activated by NH4+
4.4
-
pH 7.8, mutant enzyme Q52A
30
-
pH 7.5
2.2
-
enzyme with Na+ in the metal binding site
enzyme with K+ in the metal binding site
2
-
activated by Tl+
6.6
-
activated by Rb+
2.2
-
-
8.7
-
activated by Na+
13
-
activated by Mg2+
5.8
-
activated by Li+
11
-
activated by K+
2
-
activated by Cs+
7.3
-
activated by Ca2+
18
-
activated by Ba2+
66
-
-
0.000807
-

Ki Value (2 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 6.7, 30°C
4.2
-
pH 7.0, 30°C
7.5
-

References & Links

Links to other databases for 2-aminoisobutanoate

ChEBI
PubChem
-
PubChem