Ligand (+)-menthofuran

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Basic Ligand Information

Molecular Structure
Picture of (+)-menthofuran (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H14O
(+)-menthofuran
YGWKXXYGDYYFJU-SSDOTTSWSA-N

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(+)-pulegone + NADPH + O2 = (+)-menthofuran + NADP+ + H2O
show the reaction diagram
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(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(+)-pulegone + NADPH + O2 = (+)-menthofuran + NADP+ + H2O
show the reaction diagram
-
-
(+)-pulegone + [reduced NADPH-hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak competitive inhibition, in peppermint plants grown under low-light conditions, (+)-menthofuran is selectively retained in secretory cells and accumulated to very high levels of up to 20 mM, whereas under regular growth conditions, (+)-menthofuran levels remain very low, below 0.4 mM
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Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.3
-
pH 6.6

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.15
-
pH 6.6

References & Links

Links to other databases for (+)-menthofuran

ChEBI
PubChem
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PubChem