Ligand oligonucleotides

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Basic Ligand Information

Molecular Structure
Picture of oligonucleotides (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H28N3O22P4R5
oligonucleotides
Synonyms:
Oligo-(or poly-)nucleotides, Synthetic polynucleotides

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oligonucleotides + H2O = nucleoside 5'-phosphates
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
RNA + H2O = oligonucleotides
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + oligonucleotides = ADP + oligonucleotide 5'-phosphate
show the reaction diagram
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oligonucleotides + H2O = 5'-phosphomononucleotides
show the reaction diagram
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oligonucleotides + H2O = nucleoside 5'-phosphates
show the reaction diagram
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oligonucleotides + H2O = oligonucleotides(n-1) + 5'-mononucleotides
show the reaction diagram
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oligonucleotides + H2O = dCMP + dTMP
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
RNA-DNA*DNA hybrid + H2O = oligonucleotides
show the reaction diagram
-
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5S rRNA precursor + H2O = mature 5S rRNA + oligonucleotides
show the reaction diagram
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poly(dAdT) + H2O = oligonucleotides
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition, fragments bind without being destroyed; small to medium sized
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competitive inhibition
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with 5'-phosphate end group
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e.g. ApUp
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inhibition by single-stranded autonomously replicating sequences, highly specific inhibition by a 44-base DNA oligonucleotide carrying the autonomously replicating sequences core consensus sequence
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0222
0.143
depending on the 5'-base and the length of the oligonucleotide, pH 7.6, 37°C

References & Links

Links to other databases for oligonucleotides

ChEBI
PubChem
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