Any feedback?
Please rate this page
(ligand.php)
(0/150)

BRENDA support

Ligand taurodeoxycholic acid

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of taurodeoxycholic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H45NO6S
taurodeoxycholic acid
AWDRATDZQPNJFN-VAYUFCLWSA-N
Synonyms:
2-([4-[3,12-dihydroxyandrostan-16-yl]pentanoyl]amino)ethanesulfonic acid, 3alpha,12alpha-dihydroxy-5beta-cholanoyl taurine, deoxycholyl taurine, taurine conjugated deoxycholate, taurodeoxycholate, taurodeoxycholic acid[side 1], taurodeoxycholic acid[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl-sulfate + taurine conjugated deoxycholate = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl 5'-phosphosulfate + taurodeoxycholate = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
taurodeoxycholic acid + H2O = taurine + deoxycholic acid
show the reaction diagram
-
ATP + H2O + taurodeoxycholic acid[side 1] = ADP + phosphate + taurodeoxycholic acid[side 2]
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
deoxycholoyl-CoA + taurine = CoA + taurodeoxycholate
show the reaction diagram
-
ATP + H2O + taurodeoxycholic acid[side 1] = ADP + phosphate + taurodeoxycholic acid[side 2]
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2 to 3fold increase of activity
-
5 to 7fold less effective compared to Triton CF-54
-
11% stimulation compared to Triton CF-54
-
0.005%, 1.3fold activation
-
dependent on, maximal activity at 1-5 mM
-
1.92fold activation, pH 7.5, 25°C
-
the enzyme activity is specifically stimulated by about 2.5 mM taurodeoxycholate
-
0.5 mg/ml, 2.5fold increase of activity
-
activation
-
may substitute for Triton X-100 at 0.5%
-

Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
no carboxyl esterase activity in presence of 2-hydroxy bile salts, such as deoxycholate and taurodeoxycholate
-
slight inhibition
-
complete inhibition of the hydrolytic and synthetic activity
-
80% inactivation compared to CHAPS
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.44
-
-
0.01836
-
apparent value, in 50 mM NaH2PO4 buffer (pH 5.5), 2 mM MgCl2, at 37°C

References & Links

Links to other databases for taurodeoxycholic acid

ChEBI
PubChem
ChEBI
PubChem