Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Aminoacyl-tRNA: protein transferases
1984
Deutch, C.E.
Methods Enzymol.
106
198-205
Enzymic modification of proteins. I. General characteristics of the arginine-transfer reaction in rabbit liver cytoplasm
1969
Soffer, R.L.; Horinishi, H.
J. Mol. Biol.
43
163-175
Enzymatic modification of proteins. II. Purification and properties of the arginyl transfer ribonucleic acid-protein transferase from rabbit liver cytoplasm
1970
Soffer, R.L.
J. Biol. Chem.
245
731-737
Peptide acceptors in the arginine transfer reaction
1973
Soffer, R.L.
J. Biol. Chem.
248
2918-2921
Heparin as an inhibitor of L-arginyl-tRNA: protein arginyltransferase
1983
Kato, M.
J. Biochem.
94
2015-2022
Complete purification of arginyl-tRNA:protein arginyltransferase from hog kidney and production of its antibody
1984
Kato, M.; Nozawa, Y.
Anal. Biochem.
143
361-367
Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway
1988
Ciechanover, A.; Ferber, S.; Ganoth, D.; Elias, S.; Avram, H.; Arfin, S.
J. Biol. Chem.
263
11155-11167
Amino-terminal arginylation of chromosomal proteins by arginyl-tRNA
1976
Kaji, H.
Biochemistry
15
5121-5125
An essential role of N-terminal arginylation in cardiovascular development
2002
Kwon, Y.T.; Kashina, A.S.; Davydov, I.V.; Hu, R.G.; An, J.Y.; Seo, J.W.; Du, F.; Varshavsky, A.
Science
297
96-99
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway
1999
Kwon, Y.T.; Kashina, A.S.; Varshavsky, A.
Mol. Cell. Biol.
19
182-193
Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: Identification of residues proximal to the arsenoxide site
1995
Li, J.; Pickart, C.M.
Biochemistry
34
139-147
Arginyl-tRNA-protein transferase activities in crude supernatants of rat tissues
1999
Takao, K.; Samejima, K.
Biol. Pharm. Bull.
22
1007-1009
Preparation and usefulness of some fluorogenic substrates for assay of arginyl-tRNA-Protein transferase by HPLC
1999
Takao, K.; Xu, Y.J.; Samejima, K.; Shirahata, A.; Nitsu, M.
Anal. Biochem.
267
373-381
Crystallization and preliminary X-ray crystallographic analysis of yeast arginyl-tRNA synthetase-yeast tRNAArg complexes
2000
Delagoutte, B.; Keith, G.; Moras, D.; Cavarelli, J.
Acta Crystallogr. Sect. D
56
492-494
Gene cloning, expression, crystallization and preliminary X-ray analysis of Thermus thermophilus arginyl-tRNA synthetase
2001
Shimada, A.; Nureki, O.; Dohmae, N.; Takio, K.; Yokoyama, S.
Acta Crystallogr. Sect. D
57
272-275
Escherichia coli tRNA(4)(Arg)(UCU) induces a constrained conformation of the crucial Omega-loop of arginyl-tRNA synthetase
2004
Yao, Y.N.; Zhang, Q.S.; Yan, X.Z.; Zhu, G.; Wang, E.D.
Biochem. Biophys. Res. Commun.
313
129-134
Arginyl-tRNA synthetase with signature sequence KMSK from Bacillus stearothermophilus
2003
Li, J.; Yao, Y.N.; Liu, M.F.; Wang, E.D.
Biochem. J.
376
773-779
Effect of cysteine residues on the activity of arginyl-tRNA synthetase from Escherichia coli
1999
Liu, M.; Huang, Y.; Wu, J.; Wang, E.; Wang, Y.
Biochemistry
38
11006-11011
Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase
1999
Jakubowski, H.
Biochemistry
38
8088-8093
L-arginine recognition by yeast arginyl-tRNA synthetase
1998
Cavarelli, J.; Delagoutte, B.; Eriani, G.; Gangloff, J.; Moras, D.
EMBO J.
17
5438-5448
tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding
2000
Delagoutte, B.; Moras, D.; Cavarelli, J.
EMBO J.
19
5599-5610
Shifted positioning of the anticodon nucleotide residues of amber suppressor tRNA species by Escherichia coli arginyl-tRNA synthetase
2001
Kiga, D.; Sakamoto, K.; Sato, S.; Hirao, I.; Yokoyama, S.
Eur. J. Biochem.
268
6207-6213
Crucial role of the high-loop lysine for the catalytic activity of arginyl-tRNA synthetase
2001
Sekine, S.; Shimada, A.; Nureki, O.; Cavarelli, J.; Moras, D.; Vassylyev, D.G.; Yokoyama, S.
J. Biol. Chem.
276
3723-3726
Divergence in non-cognate amino acid recognition between class I and class II lysyl-tRNA synthetases
2004
Levengood, J.D.; Ataide, S.F.; Roy, H.; Ibba, M.
J. Biol. Chem.
279
17707-17714
The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication
2000
Lazard, M.; Agou, F.; Kerjan, P.; Mirande, M.
J. Mol. Biol.
302
991-1004
Biosynthesis and characterization of 4-fluorotryptophan-labeled Escherichia coli arginyl-tRNA synthetase
1999
Zhang, Q.S.; Shen, L.; Wang, E.D.; Wang, Y.L.
J. Protein Chem.
18
187-192
Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase
2001
Shimada, A.; Nureki, O.; Goto, M.; Takahashi, S.; Yokoyama, S.
Proc. Natl. Acad. Sci. USA
98
13537-13542
The RNA sequence context defines the mechanistic routes by which yeast arginyl-tRNA synthetase charges tRNA
1998
Sissler, M.; Giege, R.; Florentz, C.
RNA
4
647-657
Molecular dissection of arginyltransferases guided by similarity to bacterial peptidoglycan synthases
2006
Rai, R.; Mushegian, A.; Makarova, K.; Kashina, A.
EMBO Rep.
7
800-805
Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development
2008
Rai, R.; Wong, C.C.; Xu, T.; Leu, N.A.; Dong, D.W.; Guo, C.; McLaughlin, K.J.; Yates, J.R.; Kashina, A.
Development
135
3881-3889
Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice
2009
Leu, N.A.; Kurosaka, S.; Kashina, A.
PLoS ONE
4
e7734
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations
2009
Brower, C.S.; Varshavsky, A.
PLoS ONE
4
e7757
The N-end rule pathway is a sensor of heme
2008
Hu, R.; Wang, H.; Xia, Z.; Varshavsky, A.
Proc. Natl. Acad. Sci. USA
105
76-81
The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis
2009
Holman, T.J.; Jones, P.D.; Russell, L.; Medhurst, A.; Ubeda Tomas, S.; Talloji, P.; Marquez, J.; Schmuths, H.; Tung, S.A.; Taylor, I.; Footitt, S.; Bachmair, A.; Theodoulou, F.L.; Holdsworth, M.J.
Proc. Natl. Acad. Sci. USA
106
4549-4554
Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis
2012
Saha, S.; Wang, J.; Buckley, B.; Wang, Q.; Lilly, B.; Chernov, M.; Kashina, A.
Biochem. Pharmacol.
83
866-873
Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo
2011
Wang, J.; Han, X.; Saha, S.; Xu, T.; Rai, R.; Zhang, F.; Wolf, Y.I.; Wolfson, A.; Yates, J.R.; Kashina, A.
Chem. Biol.
18
121-130
Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo
2014
Wang, J.; Han, X.; Wong, C.C.; Cheng, H.; Aslanian, A.; Xu, T.; Leavis, P.; Roder, H.; Hedstrom, L.; Yates, J.R.; Kashina, A.
Chem. Biol.
21
331-337
Calreticulin-dimerization induced by post-translational arginylation is critical for stress granules scaffolding
2013
Carpio, M.A.; Decca, M.B.; Lopez Sambrooks, C.; Durand, E.S.; Montich, G.G.; Hallak, M.E.
Int. J. Biochem. Cell Biol.
45
1223-1235
Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: effects of heart-specific deletion of arginyl-tRNA-protein transferase
2013
Ribeiro, P.A.; Ribeiro, J.P.; Minozzo, F.C.; Pavlov, I.; Leu, N.A.; Kurosaka, S.; Kashina, A.; Rassier, D.E.
Int. J. Cardiol.
168
3564-3571
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding
2015
Cha-Molstad, H.; Sung, K.S.; Hwang, J.; Kim, K.A.; Yu, J.E.; Yoo, Y.D.; Jang, J.M.; Han, D.H.; Molstad, M.; Kim, J.G.; Lee, Y.J.; Zakrzewska, A.; Kim, S.H.; Kim, S.T.; Kim, S.Y.; Lee, H.G.; Soung, N.K.; Ahn, J.S.; Ciechanover, A.; Kim, B.Y.; Kwon, Y.T.
Nat. Cell Biol.
17
917-929
Spatio-temporal patterning of arginyl-tRNA protein transferase (ATE) contributes to gametophytic development in a moss
2016
Schuessele, C.; Hoernstein, S.N.; Mueller, S.J.; Rodriguez-Franco, M.; Lorenz, T.; Lang, D.; Igloi, G.L.; Reski, R.
New Phytol.
209
1014-1027
Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers
2016
Rai, R.; Zhang, F.; Colavita, K.; Leu, N.A.; Kurosaka, S.; Kumar, A.; Birnbaum, M.D.; Gyorffy, B.; Dong, D.W.; Shtutman, M.; Kashina, A.
Oncogene
35
4058-4068
Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats
2014
Brower, C.S.; Rosen, C.E.; Jones, R.H.; Wadas, B.C.; Piatkov, K.I.; Varshavsky, A.
Proc. Natl. Acad. Sci. USA
111
E4936-E4945
Ablation of Arg-tRNA-protein transferases results in defective neural tube development
2016
Kim, E.; Kim, S.; Lee, J.H.; Kwon, Y.T.; Lee, M.J.
BMB Rep.
49
443-448
Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response
2016
Kumar, A.; Birnbaum, M.; Patel, D.; Morgan, W.; Singh, J.; Barrientos, A.; Zhang, F.
Cell Death Dis.
7
e2378
Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development
2017
Wang, J.; Pavlyk, I.; Vedula, P.; Sterling, S.; Leu, N.A.; Dong, D.W.; Kashina, A.
Dev. Biol.
430
41-51
Plant arginyltransferases (ATEs)
2017
Domitrovic, T.; Fausto, A.; Silva, T.; Romanel, E.; Vaslin, M.
Genet. Mol. Biol.
40
253-260
Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum
2019
Batsios, P.; Ishikawa-Ankerhold, H.C.; Roth, H.; Schleicher, M.; Wong, C.C.L.; Mueller-Taubenberger, A.
Mol. Biol. Cell
30
453-466
Identification of targets and interaction partners of arginyl-tRNA protein transferase in the moss Physcomitrella patens
2016
Hoernstein, S.N.; Mueller, S.J.; Fiedler, K.; Schuelke, M.; Vanselow, J.T.; Schuessele, C.; Lang, D.; Nitschke, R.; Igloi, G.L.; Schlosser, A.; Reski, R.
Mol. Cell. Proteomics
15
1808-1822
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets
2017
White, M.D.; Klecker, M.; Hopkinson, R.J.; Weits, D.A.; Mueller, C.; Naumann, C.; O'Neill, R.; Wickens, J.; Yang, J.; Brooks-Bartlett, J.C.; Garman, E.F.; Grossmann, T.N.; Dissmeyer, N.; Flashman, E.
Nat. Commun.
8
14690
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration
2017
Wang, J.; Han, X.; Leu, N.A.; Sterling, S.; Kurosaka, S.; Fina, M.; Lee, V.M.; Dong, D.W.; Yates, J.R.; Kashina, A.
Sci. Rep.
7
11323
Target site specificity and in vivo complexity of the mammalian arginylome
2018
Wang, J.; Pejaver, V.R.; Dann, G.P.; Wolf, M.Y.; Kellis, M.; Huang, Y.; Garcia, B.A.; Radivojac, P.; Kashina, A.
Sci. Rep.
8
16177
The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation
2018
Shim, S.M.; Choi, H.R.; Sung, K.W.; Lee, Y.J.; Kim, S.T.; Kim, D.; Mun, S.R.; Hwang, J.; Cha-Molstad, H.; Ciechanover, A.; Kim, B.Y.; Kwon, Y.T.
Sci. Signal.
11
eaan0630
BRENDA home
Show all BRENDA pathways known for L-arginyl-tRNAArg
close all tables 
open all tables
top
