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Ligand 6-lactoyl-5,6,7,8-tetrahydropterin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.153

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ = D-sepiapterin + NADPH

668611

-

1.1.1.153

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH = tetrahydrodictyopterin + NADP+

667828

-

1.1.1.153

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ = L-sepiapterin + NADPH

668611

-

1.1.1.153

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH = L-erythro-tetrahydrobiopterin + NADP+

667828

-

1.1.1.153

4 entries

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.153

6-pyruvoyl tetrahydropterin + NADPH + H+ = 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

0

-

1.1.1.153

6-pyruvoyltetrahydropterin + NADPH = 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

0

-

1.1.1.153

2 entries

1.1.1.220

6-pyruvoyltetrahydropterin + NADPH = 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+

286310, 286308, 286309

-

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.153

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ = D-sepiapterin + NADPH

668611

-

1.1.1.153

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH = tetrahydrodictyopterin + NADP+

667828

-

1.1.1.153

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ = L-sepiapterin + NADPH

668611

-

1.1.1.153

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH = L-erythro-tetrahydrobiopterin + NADP+

667828

-

1.1.1.153

lactoyltetrahydropterin + NADPH + H+ = L-erythro-tetrahydrobiopterin + NADP+

286024

-

1.1.1.153

lactoyltetrahydropterin + NADPH = L-erythrotetrahydrobiopterin + NADP+

286024

-

1.1.1.153

6 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.153

6-pyruvoyl tetrahydropterin + NADPH + H+ = 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

0

-

1.1.1.153

6-pyruvoyltetrahydropterin + NADPH = 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

0

-

1.1.1.153

2 entries

1.1.1.220

6-pyruvoyltetrahydropterin + NADPH = 6-lactoyl-5,6,7,8-tetrahydropterin + NADP+

286310, 286308, 286309

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.153

0.008

-

pH 7.4, 37°C

286024

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

286024

3296952

On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin

1987

Smith, G.K.

Arch. Biochem. Biophys.

255

254-266

286308

4004850

Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates

1985

Milstien, S.; Kaufman, S.

Biochem. Biophys. Res. Commun.

128

1099-1107

286309

2656673

The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2-oxo)reductase

1989

Milstien, S.; Kaufman, S.

J. Biol. Chem.

264

8066-8073

286310

2511841

Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase

1989

Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.

Biochem. Biophys. Res. Commun.

164

1130-1136

667828

16527408

Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2

2006

Choi, Y.K.; Kong, J.S.; Park, Y.S.

Biochim. Biophys. Acta

1760

877-882

668611

15896778

D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2

2005

Choi, Y.K.; Park, J.S.; Kong, J.S.; Morio, T.; Park, Y.S.

FEBS Lett.

579

3085-3089

Links to other databases for 6-lactoyl-5,6,7,8-tetrahydropterin

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Show Links (1 entry)

ChEBI

PubChem