Ligand Sodium acetate

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of Sodium acetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H4NaO2
Sodium acetate
VMHLLURERBWHNL-UHFFFAOYSA-N
Synonyms:
CH3COONa, Na-acetate, NaCH3COO, NaCH3COO-, NaOAc

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sodium acetate + 2 reduced ferredoxin [iron-sulfur] cluster + H+ + O2 = ?
show the reaction diagram
-
ATP + sodium acetate + CoA = AMP + acetyl-CoA + sodium diphosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.5 g/l in reaction medium, about 10% increase of activity
-
1 g/l in reaction medium, about 15% increase of activity
-
activates mutant E328A
-
stimulates activity
-
non-linear
-
100 mM, slight activation
-
3.1fold stimulation
-
the highest increase in beta-CGTase activity is 46.9% at 1 mM sodium acetate which is 5.8fold higher than that of the control. The highest increase in gamma-CGTase activity is 39.1% at 2 mM sodium acetate which is 5.0fold higher than that of the control
-
500 mM, strong activation of unprimed reaction
-
100% activity in the presence of 750 mM sodium acetate
-
about 115% activity in the presence of 0.04 mM sodium acetate
-
20 mM, 2fold increase in activity, no effect at higher concentration at pH 7.5
-
enhances activity
-
less effective than NaCl in activating the enzyme
-
1.6 M, 4.45fold activation
-
1-2.5 M, up to 5fold increase in activity
-
required
-

Inhibitor in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 92% inhibition
-
inhibits reaction with cortisol
-
at 5°C only
-
IC50: 0.77 M
-
100 mM NaCl inhibits the activity by about 22%
-
50% inhibition at 100 mM
-
as efficient as Cl-, I-, NO2- or F-, less efficient than citrate, phosphate or sulfate
-
at concentrations higher than 100 mM
-
reduced enzymatic activity and significantly decreased Vmax/Km ratio
-
0.1 M slowly inactivates the enzyme: at 0.5 M 33% residual activity, at 1.1 M 10% residual activity
-
above 0.3 M , at pH 5
-
IFO 3134, inhibition of enzyme production
-
kosmotropic salts of the Hofmeister’s series strongly inhibit in decreasing order: sodium citrate, SO42-, acetate, Cl-
-
weak
-
100 mM, 50% onhibition
-

Metals and Ions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 400 mM regains 58% activity on refolding
-
activates
-
relative activity: 233%
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
770
-
IC50: 0.77 M

References & Links

Links to other databases for Sodium acetate

ChEBI
PubChem
-
PubChem