Ligand neamine

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Basic Ligand Information

Molecular Structure
Picture of neamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C12H26N4O6
neamine
SYJXFKPQNSDJLI-HKEUSBCWSA-N
Synonyms:
neomycin A

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B
show the reaction diagram
-
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + neamine = CoA + N3'-acetylneamine
show the reaction diagram
-
UDP-alpha-D-kanosamine + neamine = UDP + kanamycin B
show the reaction diagram
-
neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate
show the reaction diagram
-
ATP + neamine = ADP + neamine phosphate
show the reaction diagram
-
GTP + neamine = GDP + neamine 3'-phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6'-dehydroparomamine + L-glutamate = neamine + 2-oxoglutarate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
mixed-type, noncompetitive inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2
-
pH not specified in the publication, temperature not specified in the publication

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.02
-
pH not specified in the publication, temperature not specified in the publication

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00016
-
pH 7.0, 22°C
2
-
pH not specified in the publication, temperature not specified in the publication
0.013
-
in 20 mM HEPES, pH 7.4, at 25°C

References & Links

Links to other databases for neamine

ChEBI
PubChem
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PubChem