Ligand Guanidinoacetate

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Basic Ligand Information

Molecular Structure
Picture of Guanidinoacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H7N3O2
Guanidinoacetate
BPMFZUMJYQTVII-UHFFFAOYSA-N
Synonyms:
glycocyamine, Guanidinoacetic acid, Guanidoacetic acid


Show all pahtways known for Show all BRENDA pathways known for Guanidinoacetate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine
show the reaction diagram
L-ornithine + guanidinoacetate = L-arginine + glycine
show the reaction diagram
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ATP + guanidinoacetate = ADP + phosphoguanidinoacetate
show the reaction diagram
ATP + glycocyamine = ADP + N-phosphoglycocyamine
show the reaction diagram
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guanidinoacetate + H2O = glycine + urea
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + glycine = L-ornithine + guanidinoacetate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + glycocyamine = ADP + glycocyamine phosphate
show the reaction diagram
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ATP + glycocyamine = ADP + N-phosphoglycocyamine
show the reaction diagram
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ATP + glycocyamine = ADP + phosphoglycocyamine
show the reaction diagram
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guanidinoacetate + H2O = glycine + urea
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADP + phosphoguanidinoacetate = ATP + guanidinoacetate
show the reaction diagram

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
accumulates in guanidinoacetate methyltransferase deficiency, and increases the enzyme activity in the striatum and affecting memory acquisition, consolidation and retrieval of stepdown inhibitory avoidance task in rats, overview
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5 mM, relative activity 104%
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
vitamins E and C prevent the effects of intrastriatal administration of guanidinoacetate on the inhibition of creatine kinase
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weak
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.4
-
recombinant enzyme, pH 9.0, 30°C

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
6.1
-
recombinant enzyme, pH 9.0, 30°C

References & Links

Links to other databases for Guanidinoacetate

ChEBI
PubChem
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PubChem