Ligand monochlorobimane
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Basic Ligand Information
Molecular Structure
C10H11ClN2O2
monochlorobimane
SUIPVTCEECPFIB-UHFFFAOYSA-N
monochlorobimane[side 1], monochlorobimane[side 2]
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (5 results)
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monochlorobimane + ? = ?
-
monochlorobimane + glutathione = ?
-
monochlorobimane + glutathione = bimane-glutathione + HCl
-
monochlorobimane + GSH = ?
-
ATP + H2O + monochlorobimane[side 1] = ADP + phosphate + monochlorobimane[side 2]
-
Product in Enzyme-catalyzed Reactions (1 result)
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ATP + H2O + monochlorobimane[side 1] = ADP + phosphate + monochlorobimane[side 2]
-
-
Enzyme Kinetic Parameters
KM Value (8 results)
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0.004
-
isoform Gstt1a, at pH 6.5 and 25°C
0.05
-
isoform GstrI, at pH 6.5 and 25°C
0.11
-
isoform Gstm3, at pH 6.5 and 25°C
0.18
-
isoform Gstp2, at pH 6.5 and 25°C
0.22
-
isoform Gstm1, at pH 6.5 and 25°C
0.25
-
isoform Gstp1, at pH 6.5 and 25°C
References & Links
Literature References (5)
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Characterization and molecular cloning of a glutathione S-transferase from the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae)
2004
Rauch, N.; Nauen, R.
Insect Biochem. Mol. Biol.
34
321-329
Function of phytochelatin synthase in catabolism of glutathione-conjugates
2007
Blum, R.; Beck, A.; Korte, A.; Stengel, A.; Letzel, T.; Lendzian, K.; Grill, E.
Plant J.
49
740-749
The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
2011
Mukanganyama, S.; Bezabih, M.; Robert, M.; Ngadjui, B.T.; Kapche, G.F.; Ngandeu, F.; Abegaz, B.
J. Enzyme Inhib. Med. Chem.
26
460-467
Characterization of glutathione-S-transferases in zebrafish (Danio rerio)
2015
Glisic, B.; Mihaljevic, I.; Popovic, M.; Zaja, R.; Loncar, J.; Fent, K.; Kovacevic, R.; Smital, T.
Aquat. Toxicol.
158
50-62
Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1
1998
Van Luyn, M.; Muller, M.; Renes, J.; Meijer, C.; Scheper, R.; Nienhuis, E.; Mulder, N.; Jansen, P.; De Vries, E.
Int. J. Cancer
76
55-62
Links to other databases for monochlorobimane
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