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Ligand L-glutamic acid gamma-methyl ester

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Basic Ligand Information

Molecular Structure
Picture of L-glutamic acid gamma-methyl ester (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H11NO4
L-glutamic acid gamma-methyl ester
ZGEYCCHDTIDZAE-BYPYZUCNSA-N
Synonyms:
5-methyl-L-glutamate, glutamate 5-methyl ester, glutamic acid-gamma-methyl ester, glutamic acid 4-methyl ester, glutamic acid 5-methyl ester, glutamic acid gamma methyl ester, L-2-amino-5-methoxy-5-oxopentanoic acid, L-gamma-glutamyl-methylester, L-Glu-gamma-methylester, L-Glu-gamma-monomethyl ester, L-glutamate-5-methyl ester, L-glutamate-5-methylester, L-glutamate-gamma-methyl ester, L-glutamate-gamma-methylester, L-glutamate 5-methyl ester, L-glutamate gamma-methyl ester, L-glutamic acid-gamma-methyl ester, L-glutamic acid 4-methylester, L-glutamic acid gamma-methylester

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methylamine + L-glutamate-gamma-methylester = NH3 + N-methyl-L-glutamate-gamma-methyl ester
show the reaction diagram
-
glyoxylate + glutamic acid 4-methyl ester = glycine + 2-oxoglutarate 4-methyl ester
show the reaction diagram
-
ATP + 5-methyl-L-glutamate = ?
show the reaction diagram
-
L-glutamate-5-methyl ester + H2O = ?
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
only isozyme AAT2, competitive against L-asparate
-
20 mM: 63% inhibition
-
competitive towards Gln
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.4
-
pH 8.4, 37ºC
16.5
-
pH 7.0, 30°C

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
25.85
-
isozyme AAT2, 25°C, versus 2-oxoglutarate
82
-
pH 8.0, 25°C, aspartokinase III

References & Links

Links to other databases for L-glutamic acid gamma-methyl ester

ChEBI
PubChem
-
PubChem