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Ligand equol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.42

S-adenosyl-L-methionine + equol = S-adenosyl-L-homocysteine + ?

756307

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2.5.1.111

dimethylallyl diphosphate + equol = ?

760024

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2.5.1.111

dimethylallyl diphosphate + equol = diphosphate + 3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-3,4-dihydro-2H-chromen-7-ol + 3-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-chromen-7-ol

760024

-

2.5.1.111

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.31

equol 7-O-beta-D-glucuronide + H2O = equol + D-glucuronate

-

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.22

-

725173

-

2.8.2.4

potent mixed type inhibitor

662514

-

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.8.2.4

0.0004

-

-

662514

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.3.1.22

0.37

-

pH not specified in the publication, temperature not specified in the publication

725173

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

662514

15070945

Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment

2004

Harris, R.M.; Wood, D.M.; Bottomley, L.; Blagg, S.; Owen, K.; Hughes, P.J.; Waring, R.H.; Kirk, C.J.

J. Clin. Endocrinol. Metab.

89

1779-1787

725173

23265084

Inhibitory effects of isoflavonoids on rat prostate testosterone 5alpha-reductase

2012

Bae, M.; Woo, M.; Kusuma, I.W.; Arung, E.T.; Yang, C.H.; Kim, Y.U.

J. Acupunct. Meridian Stud.

5

319-322

756307

27549218

Molecular cloning and characterization of a flavonoid-O-methyltransferase with broad substrate specificity and regioselectivity from Citrus depressa

2016

Itoh, N.; Iwata, C.; Toda, H.

BMC Plant Biol.

16

180

756307

27549218

Molecular cloning and characterization of a flavonoid-O-methyltransferase with broad substrate specificity and regioselectivity from Citrus depressa

2016

Itoh, N.; Iwata, C.; Toda, H.

BMC Plant Biol.

16

180

760024

28355308

Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily

2017

Araya-Cloutier, C.; Martens, B.; Schaftenaar, G.; Leipoldt, F.; Gruppen, H.; Vincken, J.

PLoS ONE

12

e0174665

760024

28355308

Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily

2017

Araya-Cloutier, C.; Martens, B.; Schaftenaar, G.; Leipoldt, F.; Gruppen, H.; Vincken, J.

PLoS ONE

12

e0174665

756307

2 entries

760024

2 entries

Links to other databases for equol

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Show Links (1 entry)