Ligand (-)-catechin gallate

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Basic Ligand Information

Molecular Structure
Picture of (-)-catechin gallate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C22H18O10
(-)-catechin gallate
LSHVYAFMTMFKBA-CTNGQTDRSA-N
Synonyms:
(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(-)-catechin gallate + H2O = (-)-catechin + gallic acid
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(-)-catechin gallate + H2O = (-)-catechin + gallic acid
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
-
50% inhibition at 0.0015 mg/ml, B ring, C ring and gallate ring of inhibitor react with acyl transferase domain
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
9.5
-
recombinant enzyme, pH 6.0, 30°C

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.86
-
recombinant enzyme, pH 6.0, 30°C

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00128
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00024
-
-
0.0003
-
IC50: 0.3 microM

References & Links

Links to other databases for (-)-catechin gallate

ChEBI
PubChem
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PubChem