print visible entries

print all entries

Ligand GM1b

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.3.7

CMP-N-acetylneuraminate + GM1b = CMP + ?

659215

-

2.4.3.7

CMP-Neu5Ac + GM1b = ?

674352

-

2.4.3.7

CMP-N-acetylneuraminate + sialyl lactoetraosylceramide = CMP + ?

659215

-

2.4.3.7

3 entries

Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.3.2

CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b

637737, 0

-

2.4.3.2

CMP-N-acetyl-beta-neuraminate + gangloside asialo-GM1 = CMP + ganglioside GM1b

0

-

2.4.3.2

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.2.2.5

exogenous ganglioside, slight inhibition, inhibition in vivo

654609

-

Enzyme Kinetic Parameters

K_M Value (4 results)

top print hide

Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.3.7

0.33

-

isoform ST6GalNAc VI, pH 6.0, 37°C

659215

2.4.3.7

0.46

-

isoform ST6GalNAc VI, pH 6.0, 37°C

659215

2.4.3.7

0.56

-

isoform ST6GalNAc V, pH 6.0, 37°C

659215

2.4.3.7

0.9

-

isoform ST6GalNAc V, pH 6.0, 37°C

659215

2.4.3.7

4 entries

References & Links

Literature References (4)

top print hide

Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

637737

1991463

Substrate specificity of alpha 2->3-sialyltransferases in ganglioside biosynthesis of rat liver Golgi

1991

Iber, H.; van Echten, G.; Sandhoff, K.

Eur. J. Biochem.

195

115-120

654609

11170409

Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38

2001

Hara-Yokoyama, M.; Nagatsuka, Y.; Katsumata, O.; Irie, F.; Kontani, K.; Hoshino, S.; Katada, T.; Ono, Y.; Fujita-Yoshigaki, J.; Sugiya, H.; Furuyama, S.; Hirabayashi, Y.

Biochemistry

40

888-895

659215

12668675

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides

2003

Tsuchida, A.; Okajima, T.; Furukawa, K.; Ando, T.; Ishida, H.; Yoshida, A.; Nakamura, Y.; Kannagi, R.; Kiso, M.

J. Biol. Chem.

278

22787-22794

674352

16169874

Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity

2005

Tsuchida, A.; Ogiso, M.; Nakamura, Y.; Kiso, M.; Furukawa, K.; Furukawa, K.

J. Biochem.

138

237-243

Links to other databases for GM1b

top print hide

Show Links (1 entry)

ChEBI

PubChem

-