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Inhibitors of glyoxalase enzymes
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Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery
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Biochemistry
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Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs
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Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development
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Lactobacillus reuteri 2-deoxyribosyltransferase, a novel biocatalyst for tailoring of nucleosides
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Enzymatic synthesis of nucleoside analogues using immobilized 2-deoxyribosyltransferase from Lactobacillus reuteri
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Regiospecific formation of cobamide isomers is directed by CobT
2014
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Biochemistry
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Cobamide structure depends on both lower ligand availability and CobT substrate specificity
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Chemical genetics reveals a role of dCTP pyrophosphatase 1 in Wnt signaling
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Friese, A.; Kapoor, S.; Schneidewind, T.; Vidadala, S.R.; Sardana, J.; Brause, A.; Foerster, T.; Bischoff, M.; Wagner, J.; Janning, P.; Ziegler, S.; Waldmann, H.
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Structure-guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2-deoxyribosyltransferase
2019
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Enzymatic synthesis of therapeutic nucleosides using a highly versatile purine nucleoside 2'-deoxyribosyltransferase from Trypanosoma brucei
2018
Perez, E.; Sanchez-Murcia, P.; Jordaan, J.; Blanco, M.; Mancheno, J.; Gago, F.; Fernandez-Lucas, J.
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Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase
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Mittal, L.; Kumari, A.; Suri, C.; Bhattacharya, S.; Asthana, S.
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Trypanothione reductase a target for the development of anti-Trypanosoma cruzi drugs
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