Ligand a 2-oxo carboxylate

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Basic Ligand Information

Molecular Structure
Picture of a 2-oxo carboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H5O3R
a 2-oxo carboxylate
AQXVJEQKEWIYOT-UHFFFAOYSA-N
Synonyms:
2-keto acids, 2-keto fatty acid, 2-oxo-acid, 2-oxo-carboxylate, 2-oxo acid, 2-oxoacid, 2-oxo acid derivatives, 2-oxo acids, 2-oxocarboxylate, 2-oxo carboxylate, a 2-oxo-acid, a 2-oxo-carboxylate, a 2-oxoacid, a 2-oxo acid, a 2-oxocarboxylate, alpha-keto acid, alpha-Keto acids


Show all pahtways known for Show all BRENDA pathways known for a 2-oxo carboxylate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
a 2-oxocarboxylate + NADH + H+ = (2S)-2-hydroxycarboxylate + NAD+
show the reaction diagram
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2-oxoacid + CoA + oxidized ferredoxin = acyl-CoA + CO2 + reduced ferredoxin + H+
show the reaction diagram
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L-glutamine + alpha-keto acid = alpha-ketoglutarate + amino acid
show the reaction diagram
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a 2-oxo acid = an aldehyde + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
an (R)-2-hydroxycarboxylate + NADP+ = a 2-oxocarboxylate + NADPH + H+
show the reaction diagram
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(R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
show the reaction diagram
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D-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+
show the reaction diagram
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L-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+
show the reaction diagram
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an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
a 2-oxocarboxylate + NADH + H+ = (2S)-2-hydroxycarboxylate + NAD+
show the reaction diagram
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2-oxocarboxylate + NADH + H+ = (R)-2-hydroxcarboxylate + NAD+
show the reaction diagram
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E1b-thiamine diphosphate + 2-oxo-acid = E1b-thiamine diphosphate-acyl + CO2
show the reaction diagram
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2-oxoacid + CoA + oxidized ferredoxin = acyl-CoA + CO2 + reduced ferredoxin + H+
show the reaction diagram
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L-glutamine + alpha-keto acid = alpha-ketoglutarate + amino acid
show the reaction diagram
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a 2-oxo acid = an aldehyde + CO2
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
an (R)-2-hydroxycarboxylate + NADP+ = a 2-oxocarboxylate + NADPH + H+
show the reaction diagram
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(R)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
show the reaction diagram
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D-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+
show the reaction diagram
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L-2-hydroxy fatty acid + NAD+ = 2-keto fatty acid + NADH + H+
show the reaction diagram
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an (S)-2-hydroxy carboxylate + O2 = a 2-oxo carboxylate + H2O2
show the reaction diagram
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a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
show the reaction diagram
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2-oxoaldehydes + NAD+ + H2O = 2-oxo acids + NADH
show the reaction diagram
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2-oxoaldehydes + NADP+ + H2O = 2-oxo acids + NADPH
show the reaction diagram
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L-Amino acid + H2O + NAD+ = 2-Oxo acid + NH3 + NADH
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
restore activity during reaction
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
of the 3 branched chain amino acids
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Enzyme Kinetic Parameters

References & Links

Links to other databases for a 2-oxo carboxylate

ChEBI
PubChem
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PubChem