Ligand 2-aminobutanoate

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Basic Ligand Information

Molecular Structure
Picture of 2-aminobutanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H9NO2
2-aminobutanoate
RXGJTUSBYWCRBK-UHFFFAOYSA-M
Synonyms:
2-amino-n-butanoate, 2-amino-n-butyric acid, 2-aminobutanoic acid, 2-aminobutyrate, 2-aminobutyric acid, alpha-aminobutyrate, alpha-aminobutyric acid, D,L-alpha-amino-n-butyrate, D-alpha-aminobutyric acid, DL-2-aminobutanoate, DL-2-aminobutyrate, DL-2-aminobutyric acid, DL-alpha-amino-n-butyric acid, DL-alpha-aminobutanoate, DL-alpha-aminobutyric acid, L-alpha-aminobutyric acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-aminobutyrate + H2O + NADP+ = 2-oxobutyrate + NH3 + NADPH
show the reaction diagram
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L-alpha-aminobutyric acid + H2O + O2 = alpha-ketobutyrate + NH3 + H2O2
show the reaction diagram
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2-aminobutyrate + L-glutamate = 2-oxobutyrate + 2-oxoglutarate
show the reaction diagram
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2-aminobutyrate + glyoxylate = 2-oxobutanoate + glycine
show the reaction diagram
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2-aminobutyrate + glyoxylate = ?
show the reaction diagram
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ATP + 2-aminobutyric acid + tRNACys = AMP + diphosphate + L-alpha-aminobutyryl-tRNACys
show the reaction diagram
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ATP + DL-2-aminobutyrate + tRNAVal = AMP + diphosphate + DL-2-aminobutyryl-tRNAVal
show the reaction diagram
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ATP + gamma-L-Glu-L-Cys + alpha-aminobutyric acid = ADP + phosphate + gamma-Glu-L-Cys-alpha-aminobutyric acid
show the reaction diagram
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ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid = ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (62 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxobutanoate + NH3 + NADH = 2-aminobutanoate + H2O + NAD+
show the reaction diagram
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2-oxobutyrate + NADH + NH3 = 2-aminobutyrate + NAD+ + H2O
show the reaction diagram
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2-oxobutanoate + NH3 + NADH = 2-aminobutanoate + NAD+ + H2O
show the reaction diagram
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5'-phospho-pyridoxyl-2-aminobutyrate + H2O + O2 = pyridoxal 5'-phosphate + 2-aminobutyrate + H2O2
show the reaction diagram
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L-aspartate + 2-oxobutyrate = oxaloacetate + 2-aminobutyrate
show the reaction diagram
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L-alanine + 2-oxobutanoate = pyruvate + 2-aminobutanoate
show the reaction diagram
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L-asparagine + 2-oxobutanoate = 2-oxosuccinamate + 2-aminobutanoate
show the reaction diagram
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beta-alanine + 2-oxobutanoate = malonic semialdehyde + 2-aminobutanoate
show the reaction diagram
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L-lysine + 2-oxobutanoate = 2-aminoadipate 6-semialdehyde + 2-aminobutanoate
show the reaction diagram
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L-histidine + 2-oxobutyrate = imidazol-5-yl-pyruvate + 2-aminobutanoate
show the reaction diagram
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(R)-3-amino-2-methylpropanoate + 2-oxo-n-butanoate = 2-methyl-3-oxopropanoate + 2-amino-n-butanoate
show the reaction diagram
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L-alanine + 2-oxobutyrate = pyruvate + 2-aminobutanoate
show the reaction diagram
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L-glutamine + 2-oxobutyrate = 2-oxoglutaramate + 2-aminobutyrate
show the reaction diagram
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L-glutarate + 2-oxobutanoate = 2-oxoglutarate + 2-aminobutanoate
show the reaction diagram
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DL-alpha-aminobutyric acid methyl ester + H2O = DL-alpha-aminobutyric acid + methanol
show the reaction diagram
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N-chloroacetyl-2-aminobutyrate + H2O = chloroacetate + 2-aminobutyrate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
-
1 mM, relative activity 140%
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to 1-aminocyclopropane-1-carboxylate
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competitive inhibition, 10 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (60 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
25
-
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KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
35.8
-
pH 8.3, 37C, 4-methyl-2-oxopentanoate as amino group acceptor
10
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ATP-diphosphate exchange
3.7
-
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4.3
-
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Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.2
-
pH 7.0, 30C
0.033
-
-
0.15
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IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
68
-
pH 8.0, temperature not specified in the publication
80
-
above 80 mM, pH 8.0, temperature not specified in the publication

References & Links

Links to other databases for 2-aminobutanoate

ChEBI
PubChem
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PubChem