Ligand 2,5-didehydro-D-gluconate

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Basic Ligand Information

Molecular Structure
Picture of 2,5-didehydro-D-gluconate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H8O7
2,5-didehydro-D-gluconate
RXMWXENJQAINCC-DMTCNVIQSA-N
Synonyms:
2,5-diketo-D-gluconate, 2-dehydro-5-ketogluconate, D-threo-hexo-2,5-diulosonic acid


Show all pahtways known for Show all BRENDA pathways known for 2,5-didehydro-D-gluconate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,5-diketo-D-gluconate + NADPH = 5-keto-D-gluconate + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydro-D-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
-
-
2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,5-diketo-D-gluconate + NADPH + H+ = ? + NADP+
show the reaction diagram
-
2,5-diketo-D-gluconate + NADPH = 5-keto-D-gluconate + NADP+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-dehydro-D-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
-
-
2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition of isozyme B, not of isozyme A, at high concentrations
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.33
-
-
8.3
-
at pH 6.4 and 25°C

KM Value (23 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 2,5-didehydro-D-gluconate

ChEBI
PubChem
ChEBI
PubChem