Ligand (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate

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Basic Ligand Information

Molecular Structure
Picture of (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C40H51N11O18
(6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate
ULQWZJXUXMEHOO-RFXJPFPRSA-N
Synonyms:
5,10-methenyl-tetrahydropteroyl pentaglutamate, 5,10-methenyltetrahydropteroylpentaglutamate, 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1, 5,10-methylene-5,6,7,8-tetrahydropteroyl-[gamma-Glu]n+1, 5,10-methylene-5,6,7,8-tetrahydropteroylpenta-gamma-glutamate, 5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate, 5,10-methylenetetrahydropteroylpentaglutamate, 5,10-methylene tetrahydropteroylpentaglutamate
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor = sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + reduced acceptor = (+)-5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + oxidized acceptor
show the reaction diagram
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5,10-methylenetetrahydropteroylpentaglutamate + 2'-deoxyuridylate = 7,8-dihydropteroylpentaglutamate + thymidine phosphate
show the reaction diagram
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5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O = 5-formyl-tetrahydropteroyl pentaglutamate + L-serine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor = sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
show the reaction diagram
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tetrahydropteroylpentaglutamate + 2-dehydropantoate = 5,10-methylenetetrahydropteroylpentaglutamate + 3-methyl-2-oxobutanoate + H2O
show the reaction diagram
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ATP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu = ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glun+1
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for (6S)-5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate

ChEBI
PubChem
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PubChem